Isao Date, M.D.
Professor and Chairman
出身地：兵庫県西宮市生まれ、両親とも岡山出身。中学校から岡山で育つ。
専門分野
脳神経外科一般
脳動脈瘤、良性脳腫瘍の外科
機能的脳神経外科
脳の再生、細胞移植 伊達 勲のウェブサイト
くも膜下出血後の脳血管攣縮
小児脳神経外科
自己紹介およびメッセージ :
私は、昭和57年（1982年）に岡山大学医学部を卒業後、初代西本 詮教授（現岡山大学名誉教授）の主宰される当脳神経外科教室に入局し、その後平成2年（1990年）からは2代目大本堯史教授（現岡山大学名誉教授）に御指導をうけ、平成15年（2003年）に第3代の教授となり現在に至っています。
脳神経外科医としての最初の4年間は、岡山大学脳神経外科と国立岡山病院（現 岡山医療センター）脳神経外科で研修いたしました。その後、大学院生となり、脳の再生・移植の研究を行いました。当時は脳の再生の研究がまさに注目を浴び始めたころで、新しい発見に心をときめかせながら、研究を行っていました。その成果があがって、米国ニューヨーク州のロチェスター大学に昭和63年（1988年）から2年間留学いたしました。留学生活は大変楽しく充実していて、私の人生にとって最高の2年間だったと思います。「留学のすすめ」を岡山医師研修支援機構のホームページに書かせていただいております（http://www.ishikenshuushien.com/new/abroad.php?id=21）。また、基礎研究の経験はその後の私の脳神経外科医としての臨床活動を多いに広げ、また、基礎研究で培った様々な能力（計画作成能力、科学的・論理的思考力など）が臨床の現場で問題解決に役立ちました (リンク1 PDF1 脳神経外科医教育と基礎研究の意義.pdf ）。
平成2年（1990年）に帰国後、大学院生に研究指導をする一方、臨床面では、岡山大学の豊富な症例数を背景に、脳動脈瘤、脳腫瘍を中心にあらゆる分野の脳神経外科疾患の手術経験を積み重ねて参りました。平成15年（2003年）に教授に就任後は、ITを駆使した安全・正確・低侵襲な脳神経外科手術を目指し、コンピュータ連動の脳ナビゲーション手術、高解像度MRIガイド下の定位脳手術、画像の向上著しい神経内視鏡手術などをいち早く導入してきました。教授就任当時は年間300件であった手術件数は、現在年間600件と2倍になっております。良好な手術結果が患者の皆様の評価をいただいているものと思います。
岡山県のみならず、中国四国や近畿の広い地域から患者の皆様が治療を受けに来られています。外来でも病棟でも患者さんの目線にたって笑顔で接し、安心して治療を受けられるような雰囲気作りを心がけています。
医学生、研修医に対する教育にも大変力と時間を注いでいます。臨床実習では、私自らの外来で時間をかけて診断と治療の実際を学んでもらっていますし、手術室の中でも手術手順の意味合いや、モニタ画像に映し出される病変や正常解剖などをわかりやすく指導することを心がけています。
私は、米国留学から帰国後、日本脳神経外科学会の同時通訳団の一員として活動するようになり、平成15年（2003年）からは団長を務めています（リンク２ 同時通訳団座談会、 リンク３ 同時通訳ブースより）。平成24年（2012年）からは日本医学英語教育学会の理事長も務めており、医学の最先端を学び、そして歩んでいく上で、如何に英語が重要かを身にしみて感じております。このことをいつも医学生、研修医に伝える努力を続けています。
略 歴
昭和32年 (1957年）7月30日生まれ
昭和51年 (1976年） 岡山大安寺高校卒業
昭和57年 (1982年） 岡山大学医学部医学科卒業
昭和63年 (1988年） 米国ロチェスター大学医学部留学（２年間）
平成2年 (1990年） 岡山大学大学院医学研究科修了、医学博士
平成3年 (1991年） 日本脳神経外科学会専門医
平成3年 (1991年） 岡山大学脳神経外科助手
平成11年 (1999年） 岡山大学脳神経外科講師
平成15年 (2003年） 岡山大学教授
平成23年 (2011年） 岡山大学病院 副病院長
資 格（専門医等）
日本脳神経外科学会専門医
日本脳卒中学会専門医
日本脳卒中の外科学会技術指導医
日本小児神経外科学会認定医
日本神経内視鏡学会技術認定医
日本定位・機能神経外科学会技術認定医
受賞歴
平成6年(1994年） 日本脳神経外科学会ガレーヌス賞
平成8年(1996年） 岡山医学会新見（にいみ）賞
平成10年(1998年） 岡山医学会結城（ゆうき）賞
主な所属学会 世話人・理事など
全国学会会長
2008年 スパズムシンポジウム会長
2009年 日本脳神経外科コングレス会長
2009年 日本分子脳神経外科学会会長
2011年 日本神経内視鏡学会会長
2012年 日本脳神経減圧術学会会長
2012年 日本小児神経外科学会会長
2013年 日本定位・機能神経外科学会会長
2015年 日本医学英語教育学会会長
2015年 日本正常圧水頭症学会会長
2016年 日本脳卒中の外科学会会長
2019年 脳神経外科手術と機器学会会長
2019年 日本整容脳神経外科学会会長
2020年 日本脳神経外科学会会長
主な学会役員
日本脳神経外科学会理事（医療問題検討委員会委員長）
日本脳神経外科同時通訳団団長
日本医学英語教育学会理事長
日本正常圧水頭症学会理事長
日本整容脳神経外科学会理事長
スパズム･シンポジウム 世話人代表
日本脳卒中の外科学会理事
日本脳腫瘍の外科学会理事
日本頭蓋底外科学会理事
日本神経内視鏡学会理事
日本小児神経外科学会理事
日本定位・機能神経外科学会理事
日本脳神経外傷学会理事
日本ニューロリハビリテーション学会理事
日本脳循環代謝学会理事
主な論文・著書
2015
Onishi M, Ichikawa T, Kurozumi K, Inoue S,
Maruo T, Otani Y, Fujii K, Ishida J, Shimazu Y, Yoshida K, Michiue H, Chiocca
EA, Date I: Annexin A2 regulates angiogenesis and invasion phenotypes of
malignant glioma. Brain Tumor Pathology DOI 10.1007/s10014-015-0216-6, 2015
Shimazu Y, Kurozumi K, Ichikawa T, Fujii K,
Onishi M, Ishida J, Oka T, Watanabe M, Nasu Y, Kumon H, Date I: Integrin
antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3
gene therapy for malignant glioma. Gene Therapy 22:146-154, 2015
Toyoshima A, Yasuhara T, Kameda M,
Morimoto J, Takeuchi H, Wang F, Sasaki T, Sasada S, Shinko A, Wakamori T,
Okazaki M, Kondo A, Agari T, Borlongan CV, Date I: Intra-arterial
transplantation of allogeneic mesenchymal stem cells mounts neuroprotective
effects in a transient ischemic stroke model in rats: Analyses of therapeutic
time window and its mechanisms. PLOS ONE DOI 10.1371/journal.pone.0127302, 2015
Yasuhara T, Kameda M, Agari T, Date I:
Regenerative medicine for Parkinson's disease. Neurol Med Chir (Tokyo)
55:113-123, 2015
Hishikawa T, Date I, Tokunaga K,
Tominari S, Nozaki K, Shiokawa Y, Houkin K, Murayama Y, Ishibashi T, Takao H,
Kimura T, Nakayama T, Morita A: Risk of rupture of unruptured cerebral
aneurysms in elderly patients. Neurology 85:1879-1885, 2015
Watson N, Ji X, Yasuhara T, Date I,
Kaneko Y, Tajiri N , Borlongan CV: No pain, no gain: lack of exercise obstructs
neurogenesis. Cell Tranplant 24:591-597, 2015
Ishida J, Kurozumi K, Ichikawa T, Otani Y,
Onishi M, Fujii K, Shimazu Y, Oka T, Shimizu T, Date I: Evaluation of
extracellular matrix protein CCN1 as a prognostic factor for glioblastoma.
Brain Tumor Pathology 32:245-252, 2015
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2014
Hishikawa T, Sugiu K, Hiramatsu M, Haruma J,
Tokunaga K, Date I, Sakai N: Nationwide survey of the nature and risk
factors of complications in embolization of meningiomas and other intracranial
tumors: Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET.
Neuroradiology 56:139-144, 2014
Yoshida K, Ichikawa T, Kurozumi K, Yanai H, Onoda
K, Date I: Fatal glioblastoma after gamma knife radiosurgery for
arteriovenous malformation in a child. Journal of Clinical Neuroscience
21:1453-1455, 2014
Kidani N, Onishi M, Kurozumi K, Date I:
The supposed intracavernous sinus arachnoid cyst with abducens neuropathy: a
case report. Neurologia medico-chirurgica 54:582-586, 2014
Hishikawa T, Tokunaga K, Sugiu K, Date I:
Long-term outcomes in adult patients with ischemic-type moyamoya disease
involving posterior circulation. Acta Neurochirurgica (Wien) 156:1745-1751,
2014
Ishida J, Onishi M, Kurozumi K, Ichikawa T,
Fujii K, Shimazu Y, Oka T, Date I: Integrin inhibitor suppresses
bevacizumab-induced glioma invasion. Translational Oncology 7(2):292-302, 2014
Wakamori T, Agari T, Yasuhara T, Kameda M, Kondo
A, Shinko A, Sasada S, Sasaki T, Furuta T, Date I: Cognitive functions
in Parkinson's disease: Relation to disease severity and hallucination.
Parkinsonism and Related Disorders 20:415-420, 2014
Ichikawa T, Kurozumi K, Michiue H, Ishida J,
Maeda Y, Kondo E, Kawasaki A, Date I: Reduced neurotoxicity with
combined treatment of high-dose methotrexate, cyclophosphamide, doxorubicin,
vincristine and prednisolone (M-CHOP) and deferred radiotherapy for primary
central nervous system lymphoma. Clinical Neurology and Neurosurgery
127:106-111, 2014
Yasuhara T, Takahashi Y, Hijikata Y, So T,
Kumamoto S, Nakahara M, Tanoue T, Kusumegi A, Inoue T, Ogawa K, Manabe H,
Miyoshi Y, Date I, Nishida K: Infectious spondylitis: Characteristics of
geriatric patients and significance of surgery. J Spine Neurosurg 3:2, 2014
Hishikawa T, Takasugi Y, Shimizu T, Haruma J,
Hiramatsu M, Tokunaga K, Sugiu K, Date I: Cerebral vasospasm in patients
over 80 years treated by coil embolization for ruptured cerebral anerurysms.
BioMed Research International 2014:253867, 2014
Tokunaga K, Hishikawa T, Sugiu K, Date I:
Combined transarterial and transvenous approach for curative obliteration of
Klippel-Trenaunay-Weber syndrome-associated spinal perimedullary arteriovenous
fistulas. Clin Neuroradiol 25:291-294, 2014
Tajiri N, Acosta SA, Gonzales-Portillo GS,
Aguirre D, Reyes S, Lozano D, Pabon MM, Dela Pena I, Ji X, Yasuhara T, Date
I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV: Therapeutic
outcomes of transplantation of amniotic fluid-derived stem cells in
experimental ischemic stroke. Frontiers in Cellular Neuroscience 8:227, 2014
Shinko A, Agari T, Kameda M, Yasuhara T, Kondo
A, Tayra JT, Sato K, Sasaki T, Sasada S, Takeuchi H, Wakamori T, Borlongan CV, Date
I: Spinal cord stimulation exerts neuroprotective effects against
experimental Parkinson's disease. PLoS One 2014
Jul 10;9(e101468. doi: 10.1371/journal.pone.0101468. eCollection, 2014
Okuma Y, Liu K, Wake H, Liu R, Nishimura Y, Hui
Z, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi
HK, Mori S, Nishibori M: Glycyrrhizin inhibits traumatic brain injury by
reducing HMGB1-RAGE interaction. Neuropharmacology 85:18-26, 2014
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2013
Onishi
M, Ichikawa T, Kurozumi K, Fujii K, Yoshida K, Inoue S, Michiue H, Chiocca EA,
Kaur B, Date I: Bimodal anti-glioma mechanisms of cilengitide
demonstrated by novel invasive glioma models. Neuropathology 33:162-174, 2013
Tayra JT, Kameda M, Yasuhara T, Agari T, Kadota
T, Wang F, Kikuchi Y, Liang H, Shinko A, Wakamori T, Vcelar B, Weik R, Date
I: The neuroprotective and neurorescue effects of carbamylated
erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's
disease. Brain Research 1502:55-70, 2013
Onishi M, Kurozumi K, Ichikawa T, Michiue H,
Fujii K, Ishida J, Shimazu Y, Chiocca EA, Kaur B, Date I: Gene
expression profiling of the anti-glioma effect of cilengitide. SpringerPlus
2:160 doi:10.1186/2193-1801-2-160, 2013
Maruo T, Ichikawa T, Kanzaki H, Inoue S,
Kurozumi K, Onishi M, Yoshida K, Kambara H, Ouchida M, Shimizu K, Tamaru S,
Chiocca EA, Date I: Proteomics-based analysis of invasion-related
proteins in malignant gliomas. Neuropathology 33(3):264-275, 2013
Itami H, Tokunaga K, Okuma Y, Hishikawa T,
Sugiu K, Ida K, Date I: Novel 3D-CT evaluation of carotid stent volume:
greater chronological expansion of stents in patients with vulnerable plaques.
Neuroradiology 55:1153-1160, 2013
Fujii K, Kurozumi K, Ichikawa T, Onishi M,
Shimazu Y, Ishida J, Chiocca EA, Kaur B, Date I: The integrin inhibitor
cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing
oncolytic virus. Cacer Gene Therapy 20:437-444, 2013
Onishi M, Kurozumi K, Ichikawa T, Date I:
Mecanisms of tumor development and anti-angiogenic therapy in glioblastoma
multiforme. Neurologia medico-chirurgica 53:755-763, 2013
Hishikawa T, Tokunaga K, Sugiu K, Date I:
Assessment of the difference in posterior circulation involvement between
pediatric and adult patients with moyamoya disease. Journal of Neurosurgery
119(4):961-965, 2013
Yasuhara T, Agari Y, Kameda M, Kondo A,
Kuramoto S, Jing M, Sasaki T, Toyoshima A, Sasada S, Sato K, Shinko A, Wakamori
T, Okuma Y, Miyoshi Y, Tajiri N, Borlongan CV, Date I: Regenerative
medicine for epilepsy: From basic research to clinical application.
International Journal of Molecular Sciences 14:23390-23401, 2013
Sato K, Kameda M, Yasuhara T, Agari T, Baba T,
Wang F, Shinko A, Wakamori T, Toyoshima A, Takeuchi H, Sasaki T, Sasada S,
Kondo A, Borlongan, Matsumae M, Date I: Neuroprotective effects of
liraglutide for stroke model of rats. International Journal of Molecular
Sciences 14:21513-21524, 2013
Okuma Y, Wang F, Toyoshima A, Kameda M,
Hishikawa T, Tokunaga K, Sugiu K, Liu K, Haruma J, Nishibori M, Yasuhara T, Date
I: Mannitol enhances therapeutic effects of intra-arterial transplantation
of mesenchymal stem cells into the brain after traumatic brain injury.
Neuroscience letters (Neurosci Lett) 554:156-161, 2013
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2012
melted intracranial pressure transducer as cause of thermal brain injury during magnetic resonance imaging.
J Neurosurg. 2012 Oct 12. [Epub ahead of print]
Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models.Neuropathology. 2012
Sep 19. [Epub ahead of print]
Kurozumi K, Ichikawa T, Onishi M, Fujii K, Date I: Cilengitide treatment for malignant glioma: current status and future
direction. Neurol Med Chir (Tokyo). 2012;52(8):539-47.
.
Agari T, Kobayashi K, Watanabe K, Date I., Ohtsuka Y: Cryptogenic West syndrome and subsequent mesial
temporal lobe epilepsy. Epileptic Disord. 2012 Sep;14(3):334-9.
Hishikawa T, Tokunaga K, Sugiu K, Date I: Clinical and radiographic features of moyamoya disease in patients with
both cerebral ischaemia and haemorrhage. Br J Neurosurg. 2012 Aug 30. [Epub ahead of print]
Yamamoto Y, Yamamoto H, Takahashi HK, Mori S, Nishibori M: Anti-high mobility group box-1 antibody therapy for
traumatic brain injury. Ann Neurol. 2012 Sep;72(3):373-84.
Tajiri N, Acosta S, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T, Date I., Solomita MA, Antonucci I,
Stuppia L, Kaneko Y, Borlongan CV: Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell
proliferation and attenuate behavioral deficits in ischemic stroke rats. PLoS One. 2012;7(8):e43779. Epub 2012
Aug 17.
Agari T, Date I: Spinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with
Parkinson's disease. Neurol Med Chir (Tokyo). 2012;52(7):470-4.
Tokunaga K, Hishikawa T, Sugiu K, Date I: Fatal outcomes of pediatric patients with moyamoya disease associated
with pulmonary arterial hypertension. Report of two cases. Clin Neurol Neurosurg. 2012 May 22. [Epub ahead of print]
Iwado E, Ichikawa T, Kosaka H, Otsuka S, Kambara H, Tamiya T, Kondo S, Date I: Role of VEGF and matrix
metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas.
Neuropathology. 2012 Mar 15. [Epub ahead of print]
Kondo A, Date I., Endo S, Fujii K, Fujii Y, Fujimaki T, Hasegawa M, Hatayama T, Hongo K, Inoue T, Ishikawa M,
Ito M, Kayama T, Kohmura E, Matsushima T, Munemoto S, Nagahiro S, Ohno K, Okamura T, Ryu H, Shigeno T,
Shirane R, Tagusagawa Y, Tanabe H, Yamada K, Yamakami I: A proposal for standardized analysis of the results of
microvascular decompression for trigeminal neuralgia and hemifacial spasm. Acta Neurochir (Wien). 2012 May;154
(5):773-8.
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2011
Nishida A, Tokunaga K, Hishikawa T, Sugiu K, Date I: Endovascular coil embolization of a ruptured distal anterior
choroidal artery aneurysm associated with ipsilateral middle cerebral artery occlusion--case report. Neurol Med Chir
(Tokyo). 2011;51(10):716-9.
Oi S, Inagaki T, Shinoda M, Takahashi S, Ono S, Date I., Nomura S, Miwa T, Araki T, Ito S, Uchikado H, Takemoto O,
Shirane R, Nishimoto H, Tashiro Y, Matsumura A; COE-Fetal and Congenital Hydrocephalus Top 10 Japan Study
Group.Guideline for management and treatment of fetal and congenital hydrocephalus: Center Of Excellence-Fetal
and Congenital Hydrocephalus Top 10 Japan Guideline 2011. Childs Nerv Syst. 2011 Oct;27(10):1563-70.
Hayashi N, Murai H, Ishihara S, Kitamura T, Miki T, Miwa T, Miyajima M, Nishiyama K, Ohira T, Ono S, Suzuki T,
Takano S, Date I., Saeki N, Endo S: Nationwide investigation of the current status of therapeutic neuroendoscopy for
ventricular and paraventricular tumors in Japan. J Neurosurg. 2011 Dec;115(6):1147-57.
Ichikawa T, Hamazaki S, Sakai N, Otsuki Y, Wataya T, Kambara H, Shuin T, Date I: Mixed germ cell tumor and
hemangioblastoma in the cerebellum: report of a rare coexistence. Brain Tumor Pathol. 2011 Jul;28(3):279-84.
Ichikawa T, Agari T, Kurozumi K, Maruo T, Satoh T, Date I: "Double-stick tape" technique for transposition of an
offending vessel in microvascular decompression: technical case report. Neurosurgery. 2011 Jun;68(2 Suppl
Operative):377-82; discussion 382.
Hayase H, Tokunaga K, Nakayama T, Sugiu K, Nishida A, Arimitsu S, Hishikawa T, Ono S, Ohta M, Date I:
Computational fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on
postoperative patient-specific computed tomography angiography and ultrasound flow data. Neurosurgery. 2011
Apr;68(4):1096-101; discussion 1101.
Morimoto T, Yasuhara T, Kameda M, Baba T, Kuramoto S, Kondo A, Takahashi K, Tajiri N, Wang F, Meng J, Ji YW,
Kadota T, Maruo T, Kinugasa K, Miyoshi Y, Shingo T, Borlongan CV, Date I: Striatal stimulation nurtures endogenous
neurogenesis and angiogenesis in chronic-phase ischemic stroke rats. Cell Transplant. 2011;20(7):1049-64.
Wang F, Kameda M, Yasuhara T, Tajiri N, Kikuchi Y, Liang HB, Tayra JT, Shinko A, Wakamori T, Agari T, Date I:
GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson's
disease. Neurosci Res. 2011 Sep;71(1):92-8.
Kikuchi Y, Yasuhara T , Agari T , Kondo A , Kuramoto S , Kameda M , Kadota T , Baba T , Tajiri N , Wang F ,
Tayra JT , Liang H , Miyoshi Y , Borlongan CV , Date I: Urinary 8-OHdG elevations in a partial lesion rat model of
Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion. Journal of Cellular
Physiology 226(5): 1390-1398, 2011
Onishi M, Ichikawa T, Kurozumi K, Date I: Angiogenesis and invasion in glioma. Brain Tumor Pathology 28(1): 13-
24, 2011
Miyoshi Y, Yasuhara T, Date I: Posterior decompression of far-out foraminal stenosis caused by a lumbosacral
transitional vertebra - case report - Neurol Med Chir (Tokyo) 51: 153-156, 2011
Miyoshi Y, Yasuhara T, Nishida A, Tokunaga K,Sugiu K, Date I: Effectiveness of intraoperative near-infrared
indocyanine green videoangiography in a case with recurrent spinal perimedullary arteriovenous fistula. Clinical
Neurology and Neurroscience 113: 239-242, 2011
Takahashi C , Okudera H , Origasa H , Takeuchi E , Nakamura K , Fukuda O , Date I. , Tokutomi T , Aruga T ,
Sakamoto S , Kobata H , Ohta T: A simple and useful coma scale for patients with neurologic emergencies: the
emergency coma scale. American Journal of Emergency Medicine 29: 196-202, 2011
Kuramoto S, Yasuhara T, Agari T, Kondo A, Jing M, Kikuchi Y, Shinko A, Wakamori T, Kameda M, Wang F, Kin K,
Edahiro S, Miyoshi Y, Date I.BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats. Brain
Research 1368: 281-289, 2011
Yasuhara T , Ichikawa T , Miyoshi Y , Kurozumi K , Maruo T , Yanai H , Date I: Primary Germinoma in the Medulla
Oblongata: Case report. Neurologia medico-chirurgica 51(4): 326-329, 2011
Hayase H , Tokunaga K , Nakayama T , Sugiu K, Nishida A, Hishikawa T , Ono S , Ohta M , Date I: Computational
fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on postoperative
patient-specific computed tomography angiography and ultrasound flow date. Neurosurgery 68(4): 1096-1101, 2011
Yasuhara T, Miyoshi Y, Date I: Chiari Malformation with Thick Occipital Bone. Acta Med. Okayama 65: 59-61, 2011
Miyoshi Y, Yasuhara T, Date I: Noonan syndrome with occipito-atlantal dislocation and upper cervical cord
compression due to C1 dysplasia and basilar invagination. Neurol Med Chir (Tokyo) 51: 463-466, 2011
Wang F, Yasuhara T, Kameda M, Date I: Mesenchymal stem cell transplantation therapy for Parkinson's disease
and cerebral ischemia. Current Trends in Neurology 5: 13-16, 2011
Yasuhara T, Tokunaga K, Hishikawa T, Ono S, Miyoshi Y, Sugiu K, Date I: Posterior reversible encephalopathy
syndrome. J Clin Neurosci 18: 406-9, 2011
Nishida A, Tokunaga K, Hishikawa T, Sugiu K, Date I: Endovascular coil embolization of a ruptured distal anterior
choroidal artery aneurysm associated with ipsilateral middle cerebral artery occlusion: Case report. Neurologia
medico-chirurgica 51(10): 716-719, 2011
Yasuhara T, Miyoshi Y, Date I: Development of cervical subarachnoid hematoma following coronal artery stenting for
angina pectoris. Neurol Med Chir (Tokyo) 51: 664－6, 2011
Ichikawa T , Agari T , Kurozumi K , Maruo T , Satoh T , Date I: "Double stick tape" technique for transposition of an
offending vessel in microvascular decompression: Technical case report. Neurosurgery 68(ONS Suppl 2): ons375-
ons376, 2011 DOI: 10.1227/NEU.0b013e318217141c
Ichikawa T , Hamazaki S , Sakai N , Otsuki Y , Wataya T , Kambara H , Shuin T , Date I: Mixed germ cell tumor and
hemangioblastoma in the cerebellum: report of a rate coexistence. Brain Tumor Pathology 28: 279-284, 2011
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2010
Janowski M Walczak P , Date I: Intravenous route of cell delivery for treatment of neurological disorders: a meta-
analysis of preclinical results. Stem Cells and Development 19(1): 5-6, 2010
Kobayashi K , Agari T , Oka M, Yoshinaga H , Date I. , Ohtsuka Y , Gotman J : Detection of seizure-associated
high-frequency oscillations above 500Hz. Epilepsy Research 88: 139-144, 2010
Tajiri N , Yasuhara T , Shingo T , Kondo A, Yuan W, Kadota T , Wang F, Baba T , Tayra JT , Morimoto T, Jing M ,
Kikuchi Y , Kuramoto S , Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I , Furuta T , Date I: Exercise exerts
neuroprotective effects on Parkinson's disease model of rats. Brain Research 1310: 200-207, 2010
Nishiguchi M, Ono S, Iseda K, Manabe H, Hishikawa T, Date I: Effect of vasodilation by milrinone, a
phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo:
Effectiveness of cisternal injection of milrinone. Neurosurgery 66(1): 158-164, 2010
Katsumata A , Sugiu K , Tokunaga K , Kusaka N , Watanabe K , Nishida A, Namba K , Hamada H , Nakashim H ,
Date I: Optimal dose of plasmid vascular endothelial growth factor for enhancement of angiogenesis in the rat brain
ischemia model. Neurologia medico-chirurgica 50(6): 449-455, 2010
Miyoshi Y , Yasuhara T, Omori M , Date I: Infantile cervical intramedullary cavernous angioma manifesting as
hematomyelia - case report-. Neurologia medico-chirurgica 50: 677-682, 2010
Tokunaga K , Sugiu K , Yoshino K , Terai Y , Imaoka T , Handa A , Hirotsune N ,Kusaka N, Date I: Percutaneous
balloon angioplasty for acute occlusion of intracranial arteries. Neurosurgery 67[ONS Suppl 1]: ons189-197, 2010
Date I: Symptomatic unruptured cerebral aneurysms: Features and surgical outcome. Neurologia medico-chirurgica
50(9): 788-799, 2010
Wang F, Yasuhara T, Shingo T, Kameda M, Tajiri N, Yuan WJ, Kondo A, Kadota T, Baba T, Tayra JT, Kikuchi Y,
Miyoshi Y, Date I: Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian
model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α. BMC Neuroscience 11(52): 1-9,
2010
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2009
Janowski M , Date I: Systemic neurotransplantation--a problem-oriented systematic review. Rev Neurosci 20(1): 39-
60, 2009
Kadota T, Shingo T, Yasuhara T, Tajiri N, Kondo A, Morimoto T, Yuan WJ, Wang F, Baba T, Tokunaga K,
Miyoshi Y, Date I: Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon
Parkinson's disease model of rats with enhanced neurogenesis. Brain Research 1254: 120-127, 2009
Date I., Yasuhara T: Neurological disorders and neural regeneration, with special reference to Parkinson's disease
and cerebral ischemia. The Japanese Society for Artificial Organs 12: 11-16, 2009
Yasuhara T, Agari T, Kanbara H, Ichikawa T, Kurozumi K, Ono S, Miyoshi Y, Tokunaga K, Date I: Parkinsonism
Related to Brain Tumors: A Case Report and Review of the literature. The Open Neurosurgery Journal 2: 4-7, 2009
Ogawa T , Ono S , Ichikawa T , Arimitsu S), Onoda K , Tokunaga K , Sugiu K , Tomizawa K , Matusi H , Date I:
Protein transduction method for cerebrovascular disorders. Acta Med Okayama 63(1): 1-7, 2009
Satoh T, Omi M , Nabeshima M , Onoda K, Date I: Severity analysis of neurovascular contact in patients with
trigeminal neuralgia: assessment with the inner view of the 3D MR cisternogram and angiogram fusion imaging.
AJNR Am J Neuroradiol 30(3): 603-607, 2009
Kuramoto S, Yasuhara T, Agari T, Kondo A, Matsui T, Miyoshi Y, Shingo T, Date I: Injection of muscimol, a GABAa
agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdala-kindled rats.
Neurological Research 31: 407-13, 2009
Kondo A, Shingo T, Yasuhara T, Kuramoto S, Kameda M, Kikuchi Y, Matsui T, Miyoshi Y, Agari T, Borlongan CV,
Date I: Erythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the
dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Brain Res 1296: 127-36, 2009
Jing M, Shingo T, Yasuhara T, Kondo A, Morimoto T, Wang F, Baba T, Yuan WJ, Tajiri N, Uozumi T, Murakami M,
Tanabe M, Miyoshi Y, Zhao S, Date I: The combined therapy of intrahippocampal transplantation of adult neural
stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of
abnormal mossy fiber sprouting. Brain Res 1295: 203-217, 2009
Baba T , Kameda M , Yasuhara T , Morimoto T , Kondo A, Shingo T , Tajiri N , Wang F, Miyoshi Y , Borlongan CV,
Matumae M , Date I: Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and
anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/akt signaling pathway. Stroke
published online Sep 17: , 2009
Sugiu K, Agari T, Tokunaga K, Nsihida A, Date I: Endovascular treatment for bow hunter's syndrome: case report.
Minim Invas Neurosurg 52: 193-195, 2009
Sugiu K, Tokunaga K, Ono S, Nishida A, Date I: Rebleeding from a vertebral artery dissecting aneurysm after
endovascular internal trapping: adverse effect of intrathecal urokinase injection or incomplete occlusion?: Case
report. Neurologia medico-chirurgica 49(12): 597-600, 2009
====================================================
2008
Onoda K, Ono S, Tokunaga K, Sugiu K, Date I: Fenestration of the supraclinoid internal carotid artery with
associated aneurysm. Neurol Med Chir (Tokyo) 48(3):118-120, 2008
Agari T, Yasuhara T, Matusi T, Kuramoto S, Kondo A, Miyoshi Y, Shingo T, Borlongan CV, Date I: Intrapallidal
metabotropic glutamate receptor activation in a rat model of Parkinson's disease: Behavioral and histological
analysis. BRAIN RESEARCH 1203:189-196, 2008
Kondo E, Tanaka T, Miyake T, Ichikawa T, Hirai M, Adachi M, Yoshikawa K, Ichimura K, Ohara N, Moriwaki A, Date I,
Ueda R, Yoshino T:Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell
lines. Mol Cancer Ther 7(6):1461-1471, 2008
Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T,
Wang F, Leung H, Matsui T, Miyoshi Y, Date I: Neuroprotective effects of edaravone-administration on 6-OHDA-
treated dopaminergic neurons. BioMedCentral Neurosciences 9:75, 2008
Takahashi K, Yasuhara T, Shingo T, Muraoka K, Kameda M, Takeuchi A, Yano A, Kurozumi K, Agari T, Miyoshi Y,
Kinugasa K, Date I: Embryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats
demonstrated potent therapeutic effects, compared to adult neural stem cells. Brain Res 1234:172-182, 2008
Hishikawa T, Ono S, Ogawa T, Tokunaga K, Sugiu K, Date I: Effects of deferoxamine-activated hypoxia-inducible
factor-1 on the brain stem after subarachnoid hemorrhage in rats. Neurosurgery 62(1):232-241, 2008
Sugiu K, Tokunaga K, Nishida A, Hayase H, Ono S, Onoda K, Date I: Endovascular treatment for ruptured cerebral
aneurysms in elderly patients. Journal of Stroke & Cerebrovascular Disease 17(5)Supplement 1:S92, 2008
Kuramoto S, Yasuhara T, Agari T, Kondo A, Matsui T, Miyoshi Y, Shingo T, Date I: Injection of muscimol, a GABAa
agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdalakindled rats. Neurol
Res. Sep 29: 2008
Date I, Shingo T, Yasuhara T: Neurotransmitter and neurotrophic factor-secreting cell line grafting for the treatment
of Parkinson's disease. Advances in Alzheimer's and Parkinson's Disease. Abraham Fisher, Maurizio Memo,
Fabrizio Stocchi, Israel Hanin eds. Springer, New York pp51-56, 2008
Muraoka K, Shingo T, Yasuhara T, Kameda M, Yuen WJ, Uozumi T, Matsui T, Miyoshi Y, Date I: Comparison of the
therapeutic potential of adult and embryonic neural precursor cells in a rat model of Parkinson disease. Journal of
Neurosurgery 108(1):149-159, 2008
Ono S, Arimitsu S, Ogawa T, Manabe H, Onoda K, Tokunaga K, Sugiu K, Date I: Continuous evaluation of regional
oxygen saturation in cerebral vasospasm after subarachnoid haemorrhage using INVOS®, portable near infrared
spectrography. Acta Neurochir Suppl 104:215-218, 2008
Ono S, Hishikata T, Ogawa T, Nishiguchi M, Onoda K, Tokunaga K, Sugiu K, Date I: Effect of deferoxamine-activated
hypoxia inducible factor-1 on the brainstem following subarachnoid haemorrhage. Acta Neurochir Suppl 104:69-73,
2008
Ogawa T, Ono S, Ichikawa T, Michiue H, Arimitus S, Onoda K, Tokunaga K, Sugiu K, Tomizawa K, Matusi H,
Date I: Direct protein transduction method to cerebral arteries by using 11R: new strategy for the treatment of
cerebral vasospasm after subarachnoid haemorrhage. Acta Neurochir Suppl 104:161-163, 2008
Ogawa T, Ono S, Ichikawa T, Arimitsu S, Onoda K, Tokunaga K, Sugiu K, Tomizawa K, Matusi H, Date I:
Endothelia nitric oxide synthase-11R protein therapy for prevention of cerebral vasospasm in rats: a preliminary
report. Acta Neurochir Suppl 104:165-167, 2008
Iseda K, Ono S, Onoda K, Satoh M, Manabe H, Nishiguchi M, Takahashi K, Tokunaga K, Sugiu K, Date I:
Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage.
Journal of Neurosurgery 107:128ー135, 2007
Yasuhara T, Hara K, Maki M, Matsukawa N, Fujino H, Date I, Borlongan CV: Lack of exercise, via hindlimb
suspension, impedes endogenous neurogenesis. Neuroscience 149:182-191, 2007
Yasuahra T, Shingo T, Date I: Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease.
Acta Med Okayama 61(2):51-56, 2007
Yasuhara T, Date I: Intracerebral transplantation of genetically engineered cells for Parkinson's disease: Toward
clinical application. Cell Transplantation 16:125-132, 2007
Watanabe K, Sugiu K, Tokunaga K, Sasahara W, Ono S, Date I:Packing efficacy of hydrocoil system: in vitro study
using ruptured aneurysm model. Neurosurg Rev 30:127-130, 2007
Satoh T, Onoda K, Date I: Preoperative simulation for microvascular decompression in patients with idiopathic
trigeminal neuralgia: Visualization with three-dimensional magnetic resonance cisternogram and angiogram fusion
imaging. Neurosurgery 60(1):104-114, 2007
Satoh T, Onoda K, Date I: Fusion imaging of three-dimensional magnetic resonance cisternograms and angiograms
for the assessment of microvascular decompression in patients with hemifacial spasms. Journal of Neurosurgery 106
(1):82-89, 2007
Tsuboi T, Tokunaga K, Shingo T, Itoh T, Mandai S, Kinugasa K, Date I: Differentiation between intradural and
extradural locations of juxta-dural ring aneurysms by using contrast-enhanced 3-dimensional time-of-flight magnetic
resonance angiography. Surgical Neurology 67(4):381-387, 2007
Ogawa T, Ono S, Ichiakwa T, Arimitsu S, Onoda K, Tokunaga K, Sugiu K, Tomizawa K, Matsui H, Date I: Novel
protein transduction method by using 11R: an effective new drug delivery system for the treatment of
cerebraovascular diseases. Stroke 38(4):1354-1361, 2007
Sugiu K, Tokunaga K, Nishida A, Sasahara W, Watanabe K, Ono S, Onoda K, Date I: Triple-catheter technique in the
transvenous coil emabolization of an isolated sinus dural arteriovenous fistula. Neurosrugery 61(3 Suppl):81-85,
2007
Kameda M, Shingo T, Takahashi K, Muraoka K, Kurozumi K, Yasuhara T, Maruo T, Tsuboi T, Uozumi T, Matsui T,
Miyoshi Y, Hamada H, Date I: Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate
and integrate after intracerebral transplantation in rats with transient forebrain ischemia. European Journal of
Neuroscience 26:1462-1478, 2007
==================================
2006
Yasuhara T, Borlongan CV, Date I: Ex vivo gene therapy: transplantation of neurotrophic factor-secreting cells for
cerebral ischemia. Frontiers in Bioscience 11:760-775, 2006
Kusaka N, Tamiya T, Adachi Y, Katayama S, Namba S, Tokunaga K, Sugiu K, Date I, Ohmoto T: Adult unilateral
moyamoya disease with familial occurrence in two definite cases: a case report and review of the literature.
Neurosurgical Review 29(1):82-87, 2006
Tokunaga K, Tamiya T, Date I: Transient memory disturbance after removal of an intraventricular trigonal meningioma
by a parieto-occipital interhemispheric precuneus approach: case report. Surgical Neurology 65:167-169, 2006
Muraoka K, Shingo T, Yasuhara T, Kameda M, Yuan W, Hayase H, Matsui T, Miyoshi Y, Date I: The high integration
and differentiation potential of autologous neural stem cell transplantation compared with allogeneic transplantation in
adult rat hippocampus. Experimental Neurology 199:311-327, 2006
Kobayashi K, Yasuhara T, Agarai T, Muraoka K, Kameda M, Yuan W, Hayase H, Matsui T, Miyoshi Y, Shingo T,
Date I: Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat. Brain Research
1102:1-11, 2006
Nakama H, Ohsugi K, Otsuki T, Date I, Kosuga M, Okuyama T, Sakuragawa N: Encapsulation cell therapy for
mucopolysaccharidosis type VII using genetically engineered immortalized human amniotic epithelial cells. Tohoku J
Exp Med 209(1):23-32, 2006
Tamiya T, Takao S, Ichikawa T, Chayama K, Date I: Successful chemotherapy for congenital malignant gliomas: A
report of two cases. Pediat Neurosurg 42:240-244, 2006
Saoth T, Omi M, Ohsako C, Fujiwara K, Tsuno K, Sasahara W, Onoda K, Tokunaga K, Sugiu K, Date I: Differential
Diagnosis of the Infundibular Dilation and Aneurysm of Internal Carotid Artery: Assessment with Fusion Imaging of
3D MR Cistenography/Angiography. AJNR Am J Neuroradiol 27:306-312, 2006
Date I, Shingo T, Yasuhara T: Genetically modified cell line grafting for the treatment of Parkinson's disease.
Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology. Kanno T, Kato Y (eds), Springer-Verlag
Tokyo, Tokyo 108-113, 2006
Date I, Shingo T, Yasuhara T, Takahashi K, Muraoka K: Neuroprotection and repair by using adult-derived neural
stem cell grafting for neurological disorders. Minimally Invasive Neurosurgery and Multidisciplinary
Neurotraumatology. Kanno T, Kato Y (eds), Springer-Verlag Tokyo, Tokyo 131-137, 2006
====================================
2005
Borlongan CV, Date I: Toxicity of semaphorin3A for dopaminergic neurons. Neuroscience Letters 382:61-65, 2005
Sugiu K, Tokunaga K, Watanabe K, Sasahara W, Ono S, Tamiya T, Date I: Emergent endovascular treatment of
ruptured vertebral artery dissecting aneurysms. Neuroradiology 47:158-164, 2005
Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Ishii K, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K,
Honmou O, Houkin K, Date I, Hamada H: Mesenchymal stem cells that produce neurotrophic factors reduce ischemic
damage in the rat middle cerebral artery occlusion model. Molecular therapy 11:96-104, 2005
Katsuragi S, Ikeda T, Date I, Shingo T, Yasuhara T, Mishima K, Aoo N, Harada K, Egashira N, Iwasaki K, Fujiwara M,
Ikenoue T: Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting
learning impairment following neonatal hypoxic-ischemica brain insult in rats. Am J Obstet Gynecol 192:1028-1037,
2005
Katsuragi S, Ikeda T, Date I, Shingo T, Yasuhara T, Ikenoue T: Grafting of glial cell line-derived neurotrophic factor
secreting cells for hypoxic-ischmic encephalopathy in neonatal rats. Am J Obstet Gynecol 192:1137-1145, 2005
Yasuhara T, Shingo T, Muraoka K, Kobayashi K, Takeuchi A, Yano A, Yuan WJ, Kameda M, Matsui T, Miyoshi Y,
Date I: Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell
demonstrating strong neuroprotective effects in a rat model of Parkinson disease. J Neurosurg 102:80-89, 2005
Yasuhara T, Shingo T, Muraoka K, Yuan WJ, Kameda M, Takeuchi A, Yano A, Nishio S, Matusi T, Miyoshi Y,
Hamada H, Date I: The differences between high and low-dose administration of VEGF to dopaminergic neurons of
in vitro and in vivo Parkinson's disease model. Brain Research 1038:1-10, 2005
Miyoshi T, Otsuka F, Suzuki J, Inagaki K, Takeda M, Kano Y, Yamashita T, Ogura T, Date I, Tanaka Y, Hashimoto K,
Makino H: Periodic secretion of adrenocorticotropin in a patient with cushing's disease manifested during pregnancy.
Endocrine Journal 52(3):287-292, 2005
Ono S, Onoda K, Tokunaga K, Sugiu K, Date I: Combination therapy for cerebral vasospasm after SAH: Importance
of spinal drainage and intraarterial injection of fasudil hydrochloride. 13 World Congress of Neurological surgery,
June19-24:379-385, 2005
Yano A, Shingo T, Takeuchi A, Yasuhara T, Kobayashi K, Takahashi K, Muraoka K, Matsui T, Miyoshi Y, Hamada H,
Date I: Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic
effects on focal cerebral ischemia. J Neurosurg 103:104-114, 2005
Yasuhara T, Shingo T, Muraoka K, Kameda M, Agari T, Yuan WJ, Hayase H, Hamada H, Borlongan CV, Date I:
Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain Research 1053:10-18, 2005
Kusaka N, Sugiu K, Tokunaga K, Katsumata A, Nishida A, Namba K, Hamada H, Nakashima H, Date I: Enhanced
brain angiogenesis in chronic cerebral hypoperfusion after administration of plasmid human vascular endothelial
growth factor in combination with indirect vasoreconstructive surgery. Journal of Neurosurgery 103:882-890, 2005
Sugiu K, Tokunaga K, Watanabe K, Sasahara W, Tagawa M, Tamesa N, Ono S, Onoda K, Date I: Endovascular
treatment for elderly patients with ruptured aneurysm. Acta Neurochirurgica Supplementum 94:7-9, 2005
Satoh M, Date I, Ohmoto T, Perkins E, Parent AD: The expression and activation of matrix metalloproteinase-1 after
subarachnoid haemorrhage in rats. Acta Neurochir (Wien) 147(2):187-193, 2005
Satoh T, Omi M, Ohsako T, Katsumata A, Yoshimoto Y, Tsuchimoto S, Onoda K, Tokunaga K, Sugiu K, Date I:
Visualization of Aneurysmal Contours and Perianeurysmal Environment with Conventional and Transparent 3D MR
Cisternography. AJNR Am J Neuroradiol 26:313-318, 2005
Satoh T, Omi M, Ohsako T, Katsumata A, Yoshimoto Y, Tsuchimoto S, Onoda K, Tokunaga K, Sugiu K, Date I:
Influence of Perianeurysmal Environment on the Deformation and Bleb Formation of the Unruptured Cerebral
Aneurysm: Assessment with Fusion Imaging of 3D MR Cisternography and 3D MR Angiography. AJNR Am J
Neuroradiol 26:2010-2018, 2005
Michiue H, Tomizawa K, Matsushita M, Tamiya T, Lu YF, Ichikawa T, Date I, Matsui H: Ubiquitination-Resistant p53
Protein Transduction Therapy Facilitates Anti-Cancer Effect on the Growth of Human Malignant Glioma Cells. FEBS
Letter 579:3965-3969, 2005
Michiue H, Tomizawa K, Wei FW, Tamiya T, Matsushita M, Lu YF, Ichikawa T, Date I, Matsui H: The NH2 terminus of
influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53
protein transduction. Journal of Biological Chemistry 280:8285-8289, 2005
Ichikawa T, Wakisaka A, Daido S, Takao S, Tamiya T, Date I, Koizumi S, Niida Y: A case of solitary subependymal
giant cell astrocytoma: Two somatic hits of TSC2 in the tumor, without evidence of somatic mosaicism. Journal of
Molecular Diagnostics 7(4):544-549, 2005
Matsushita H, Uenaka A, Ono T, Hasegawa K, Sato S, Koizumi A, Nakagawa K, Toda M , Shingo T, Ichikawa T,
Noguchi Y, Tamiya T, Furuta T, Kawase T, Date I, Nakayama E: Identification of glioma-specific RFx4-E and -F
isoforms and humoral immune response in patients. Cancer Science 96(11):801-809, 2005
========================================
2004
Otsuka S, Tamiya T, Ono Y, Michiue H, Kurozumi K, Daido S, Kambara H, Date I, Ohmoto T: The relationship
between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in
intracranial meningiomas. Journal of Neurooncology 70:349-357, 2004
Yasuhara T, Shingo T, Date I: The potential role of vascular endothelial growth factor in the central nervous system.
Rev Neurosci 15:293-307, 2004
Yasuhara T, Sugiu K, Kakishita M, Date I: Pseudoxanthoma elasticum with carotid rete mirabile. Clin Neurol
Neurosurg 106:114-117, 2004
Yasuhara T, Shingo T, Kobayashi K, Takeuchi A, Yano A, Muraoka K, Matsui T, Miyoshi Y, Hamada H, Date I:
Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of
Parkinson's disease. Eur J Neurosci 19:1494-1504, 2004
Tokunaga K, Sugiu K, Kameda M, Sakai K, Terasaka K, Higashi T, Date I: Persistent primitive trigeminal artery-
cavernous sinus fistula with intracerebral hemorrhage: endovascular treatment using detachable coils in a
transarterial double-catheter technique. J Neurosurg 101:697-699, 2004
Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O,
Houkin K, Date I, Hamada H: BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce
infarct size in the rat middle cerebral artery occlusion model. Mol Ther 9:189-197, 2004
Miyoshi T, Otsuka F, Takeda M, Inagaki K, Suzuki J, Ogura T, Date I, Hashimoto K, Makino H: Effect of cabergoline
treatment on Cushing's disease caused by aberrant adrenocorticotropin-secreting macroadenoma. J Endocrinol
Invest 27:1055-1059, 2004
Ono S, Ichikawa T, Ono Y, Date I: Large supratentorial ectopic ependymoma with massive calcification and cyst
formation. Neurol Med Chir 44:424-428, 2004
Sugiu K, Tokunaga K, Sasahara W, Watanabe K, Nishida A, Katsumata A, Kusaka N, Date I, Ohmoto T,
Rufenacht DA: Training in neurovascular intervention: usefulness of in-vitro model and clinical practice.
Interventional Neuroradiology 10 (Suppl 1):107-112, 2004
Daido S, Takao S, Tamiya T, Ono Y, Terada K, Ito S, Ouchida M, Date I, Ohmoto T, Shimizu K: Loss of
heterozygosity on chromosome 10q associated with malignancy and prognosis in astrocytic tumors, and discovery of
novel loss regions. ONCOLOGY REPORTS 12:789-795, 2004
Hishikawa T, Ono S, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date I: Expression of hypoxia inducible factor-1 in
a rat subarachnoid hemorrhage model. Cerebral Vasospasm Advances in Research and Treatment. Macdonald RL
(ed), Thieme Medical Publishers, Inc. New York 134-137, 2004
Hishikawa T, Ono S, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date I: Intravascular adenoviral gene transfection
of monkey cerebra arteries using micro-balloon catheters. Cerebral Vasospasm Advances in Research and
Treatment. Macdonald RL (ed), Thieme Medical Publishers, Inc., New York 112-115, 2004
Ono S, Hishikawa T, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date I: Therapeutic strategies for cerebral
vasospasm after SAH: efficacy of a combination of intraventricular urokinase and intra-arterial Fasudil. Cerebral
Vasospasm Advances in Research and Treatment. Macdonald RL (ed), Thieme Medical Publishers, Inc., New York
296-299, 2004
Ono S, Hishikawa T, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date I: What is the key factor expressed in
human spastic arteries after SAH? Cerebral Vasospasm Advances in Research and Treatment. Macdonald RL (ed),
Thieme Medical Publishers, Inc., New York 129-133, 2004
Nishiguchi M, Ono S, Hishikawa T, Nishio S, Tokunaga K, Sugiu K, Date I: Phosphodiesterase III inhibitor for the
treatment of chronic cerebral vasospasm in dogs. Cerebral Vasospasm Advances in Research and Treatment.
Macdonald RL (ed), Thieme Medical Publishers, Inc., New York 160-163, 2004
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2003
Ono S, Date I, Onoda K, Ohmoto T: Time course of the diameter of the major cerebral arteries after subarachnoid
hemorrhage using corrosion cast technique. Neurol Res 25:383-389, 2003
Terada H, Matsushita M, Lu, YF, Shirai T, Li ST, Tomizawa K, Moriwaki A, Nishio S, Date I, Ohmoto T, Matsui H:
Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem 87:
1145-1151, 2003
Yoshida H, Date I, Shingo T, Fujiwara K, Kobayashi K, Miyoshi Y, Ohmoto T: Stereotactic transplantation of a
dopamine-producing capsule into the striatum for treatment of Parkinson disease: a preclinical primate study.
J Neurosurg 98:874-881, 2003
Yasuhara T, Tamiya T, Meguro T, Ichikawa T, Sato Y, Date I, Nakashima H, Ohmoto T: Glioblastoma with metastasis
to the spleen: case report. Neurol Med Chir (Tokyo) 43:452-456, 2003
Fujiwara K, Date I, Shingo T, Yoshida H, Kobayashi K, Takeuchi A, Yano A, Tamiya T, Ohmoto T: Reduction of infarct
volume and apoptosis by grafting of encapsulated basic fibroblast growth factor-secreting cells in a model of middle
cerebral artery occlusion in rats. J Neurosurg 99:1053-1062, 2003
Shingo T, Date I, Yano A, Kobayashi K, Takeuchi A, Yasuhara T, Ohmoto T: Cell therapy for cerebral ischemia using
vascular endothelial growth factor-secreting cells. Molecular mechanism and epochal therapeutics of ischemic stroke
and dementia. Abe K (ed), Elsevier Science BV, Amsterdam 483-487, 2003
Date I, Shingo T, Ohmoto T: Neurotrophic factor delivery by encapsulated cell grafts. Molecular mechanism and
epochal therapeutics of ischemic stroke and dementia. Abe K (ed), Elsevier Science BV, Amsterdam 247-251, 2003
================================================
2002
Naganawa Y, Ohsugi K, Kase R, Date I, Sakuraba H, Sakuragawa N: In vitro study of encapsulation therapy for
Fabry disease using genetically engineered CHO cell line. Cell Transplant 11:325-329, 2002
Shingo T, Date I, Yoshida H, Ohmoto T: Neuroprotective and restorative effects of intrastriatal grafting of
encapsulated GDNF-producing cells in a rat model of Parkinson's disease. J Neurosci Res 69:946-954, 2002
Seth K, Agrawal AK, Date I, Seth PK: The role of dopamine in manganese-induced oxidative injury in rat
pheochromocytoma cells. Hum Exp Toxicol 21:165-170, 2002
=====================================
2001
Fujiwara K, Date I, Shingo T, Yoshida H, Kobayashi K, Takeuchi A, Tamiya T, Ohmoto T: Neurotrophic factor-secreting
cell grafting for cerebral ischemia: preliminary report. Cell Transplant 10:419-422, 2001
Nakajima M, Date I, Takahashi K, Ninomiya Y, Asari S, Ohmoto T: Effects of aging on cerebral vasospasm after
subarachnoid hemorrhage in rabbits. Stroke 32:620-628, 2001
Tokunaga K, Kusaka N, Nakashima H, Date I, Ohmoto T: Coil embolization of intradural pseudoaneurysms caused by
arterial injury during surgery: report of two cases. AJNR Am J Neuroradiol 22:35-39, 2001
Date I, Shingo T, Yoshida H, Fujiwara K, Kobayashi K, Takeuchi A, Ohmoto T: Grafting of encapsulated genetically
modified cells secreting GDNF into the striatum of parkinsonian model rats. Cell Transplantation 10:397-401, 2001
Date I, Nakajima M, Takahashi K, Ono S, Satoh M, Iseda K, Manabe H, Ninomiya Y, Asari S, Ohmoto T: Comparison
of cerebral vasospasm between young and old animals: preliminary report. Acta Neurochir Suppl 77:111-114, 2001
Satoh M, Date I, Nakajima M, Takahashi K, Iseda K, Tamiya T, Ohmoto T, Ninomiya Y, Asari S: Inhibition of poly(ADP-
ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits. Stroke 32:225-231,
2001
Iseda K, Date I, Manabe H, Nishiguchi M, Ono S, Ohmoto T: Caspase inhibitor attenuates cerebral vasospasm in
animal models of subarachnoid hemorrhage. Proceedings 12th World Congress of Neurosurgery (World Federation of
Neurosurgical Societies). 150-151, 2001
Date I, Shingo T, Ohmoto T: Neurotrophic factor delivery by encapsulated cell grafting technique. Molecular
Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Abe K (ed), Elsevier Science B.V., Amsterdam 289-
296, 2001
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
2000
Date I, Shingo T, Yoshida H, Fujiwara K, Kobayashi K, Ohmoto T: Grafting of encapsulated dopamine-secreting cells in
Parkinson's disease: long-term primate study. Cell Transplantation 9:705-709, 2000
Aoi M, Date I, Tomita S, Ohmoto T: The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic
system in hemiparkinsonian rats: behavioral and histological studies using two different dosages. Neurosci Res 36:319
-325, 2000
Aoi M, Date I, Tomita S, Ohmoto T: Single or continuous injection of glial cell line-derived neurotrophic factor into the
striatum induces recovery of the nigrostriatal dopaminergic system. Neurol Res 22:832-836, 2000
Aoi M, Date I, Tomita S, Ohmoto T: Single administration of GDNF into the striatum induced protection and repair of
the nigrostriatal dopaminergic system in the intrastriatal 6-hydroxydopamine injection model of hemiparkinsonism.
Restor Neurol Neurosci 17:31-38, 2000
Aoi M, Date I, Tomita S, Ohmoto T: GDNF induces recovery of the nigrostriatal dopaminergic system in the rat brain
following intracerebroventricular or intraparenchymal administration. Acta Neurochir (Wien) 142:805-810, 2000
Date I: Neural transplantation and trophic factors for the treatment of Parkinson's disease. Stem Cell Biology and
Cellular and Molecular Treatment. Sakuragawa N(ed), National Center of Neurology and Psychiatry, Tokyo 75-87,
2000
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
1999
Date I, Ohmoto T: Neural transplantation for Parkinson's disease. Cell Mol Neurobiol 19:67-78, 1999
Date I, Sugiu K, Ohmoto T: A Giant thrombosed aneurysm of the petrous carotid artery presenting with cavernous
sinus syndrome: Case report. Skull Base Surg 9:65-70, 1999
Yoshida H, Date I, Shingo T, Fujiwara K, Miyoshi Y, Furuta T, Ohmoto T: Evaluation of reaction of primate brain to
grafted PC12 cells. Cell Transplant 8:427-430, 1999
Date I, Ono S, Takahashi K, Nakajima M, Onoda K, Ogihara K, Shiota T, Asari S, Ohmoto T, Ninomiya Y, Yabuno N:
Quantitative and qualitative analysis of hemolysate-induced cerebral vasospasm in rats using corrosion cast
technique. Cerebral Vasospasm VI. Dorsch N (ed), Oslington Consulting PTY LTD, Leichhardt, Australia 36-39, 1999
Ono S, Date I, Takahashi K, Nakajima M, Shiota T, Asari S, Ohmoto T, Ninomiya Y, Yabuno N: In vivo analysis of
transcription factors in rat basilar artery with cerebral vasospasm after subarachnoid hemorrhage. Cerebral
Vasospasm VI, Dorsch N (ed), Oslington Consulting PTY LTD, Leichhardt, Australia 86-88, 1999
＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝＝
1998
Ono S, Date I, Onoda K, Shiota T, Ohmoto T, Ninomiya Y, Asari S, Morishita R: Decoy administration of NF-κB into the
subarachnoid space for cerebral angiopathy. Hum Gene Ther 9:1003-1011, 1998
Date I, Ohmoto T: Long-term outcome of surgical treatment of intracavernous giant aneurysms. Neurol Med Chir 38
(Suppl):62-69, 1998
Date I, Asari S, Ohmoto T: Cerebral aneurysms causing visual symptoms: their features and surgical outcome. Clin
Neurol Neurosurg 100(4):259-267, 1998
Date I, Ogihara K, Tamiya T, Ohmoto T: Kissing bilateral large carotid-ophthalmic aneurysms: a case report.
Neurosurg Rev 21:281-283, 1998
Date I, Asari S, Ohmoto T: Tips for preventing CSF rhinorrhea after acoustic neurinoma surgery: technical note. Skull
Base Surg 8:181-183, 1998
Date I, Shingo T, Yoshida H, Fujiwara K, Ohmoto T: Delivery of neurotransmitter and neurotrophic factors into the brain
using an encapsulated cell grafting technique. Restor Neurol Neurosci 13:222-223, 1998
Yoshida H, Date I, Shingo T, Fujiwara K, Ohmoto T: Evaluation of encapsulated and unencapsulated PC12 cells
grafted into the primate brain. Restor Neurol Neurosci 13:223-224, 1998
system both in young and aged parkinsonian mice. Neuroreport 9:2365-2369, 1998
Fujiwara K, Date I, Shingo T, Yoshida H, Imaoka T, Ohmoto T: Establishment of a glucocorticoid-inducible L-DOPA and
dopamine-producing PC12 cell line using non-viral transfection of human tyrosine hydroxylase gene. Restor Neurol
Neurosci 13:229, 1998
Imaoka T, Date I, Ohmoto T, Nagatsu T: Significant behavioral recovery in Parkinson's disease model by direct
intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex. Hum Gene Ther 9:1093-
1102, 1998
Imaoka T, Date I, Ohmoto T, Yasuda T, Tsuda M: In vivo gene transfer into the adult mammalian central nervous
system by continuous injection of plasmid DNA-cationic liposome complex. Brain Res 780:119-128, 1998
Date I, Ohmoto T: ntracerebral chromaffin cell and encapsulated cell grafting for Parkinson's disease : a review The
adrenal chromaffin cell. I. Archetype and exemplar of cellular signalling in secretory control. Kanno T, Nakazato Y,
Kumakura K(ed), Hokkaido University Press, Sapporo 333-342, 1998
=========================================
1997
Ohmoto T, Yabuno N, Date I: Surgical treatment of transitional internal carotid aneurysms. J Clin Neurosci 4:373-377,
1997
Ono S, Date I, Nakajima M, Onoda K, Ogihara K, Shiota T, Asari S, Ninomiya Y, Yabuno N, Ohmoto T: Three-
dimensional analysis of vasospastic major cerebral arteries in rats with the corrosion cast technique. Stroke 28:1631-
1638, 1997
Date I, Akioka T, Ohmoto T: Penetration of the optic chiasm by a ruptured anterior communicating artery aneurysm.
J Neurosurg 87:324-326, 1997
hemiparkinsonian rats with co-grafted polymer-encapsulated human NGF-secreting cells. Exp Neurol 147:10-17, 1997
Ono T, Date I, Imaoka T, Shingo T, Furuta T, Asari S, Ohmoto T: Evaluation of intracerebral grafting of dopamine-
secreting PC12 cells into allogeneic and xenogeneic brain. Cell Transplantation 6:511-513, 1997
==================================
1996
Date I, Ohmoto T: Parkinson's disease (Neurosurgical forum). J Neurosurg 85:528-529, 1996
Date I, Ohmoto T, Imaoka T, Ono T, Hammang JP, Francis J, Greco C, Emerich DF: Cografting with polymer-
encapsulated human nerve growth factor-secreting cells and chromaffin cell survival and behavioral recovery in
hemiparkinsonian rats. J Neurosurg 84:1006-1012, 1996
Date I, Miyoshi Y, Imaoka T, Ono T, Furuta T, Asari S, Ohmoto T Iwata H: Preliminary report of polymer encapsulated
dopamine-secreting cell grafting into the brain. Cell Transplantation 5:S17-S19, 1996
Date I, Imaoka T, Ono T, Shingo, T, Furuta T, Asari S, Emerich DF, Ohmoto T: Encapsulated NGF-secreting cell
grafting into the brain: increased chromaffin cell survival and functional recovery in parkinsonian model rats. Restor
Neurol Neurosci 10:182, 1996
Date I, Ohmoto T: Neural transplantation and trophic factors in Parkinson's disease: special reference to chromaffin
cell grafting, NGF support from pretransected peripheral nerve and encapsulated dopamine-secreting cell grafting.
Exp Neurol 137:333-344, 1996
Date I: Parkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting: basic and clinical studies.
Brain Res Bull 40:1-19, 1996
Date I, Imaoka T, Miyoshi Y, Ono T, Asari S, Ohmoto T: Chromaffin cell survival and host dopaminergic fiber recovery
in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve: case
report. J Neurosurg 84:685-689, 1996
Date I, Ohmoto T, Imaoka T, Shingo T, Emerich DF: Chromaffin cell survival from both young and old donors is
enhanced by cografts of polymer-encapsulated human NGF-secreting cells. Neuroreport 7:1813-1818, 1996
Miyoshi Y, Date I, Ohmoto T, Iwata H: Histological analysis of microencapsulated dopamine-secreting cells in agarose/
poly(styrene sulfonic acid) mixed gel xenotransplanted into the brain. Exp Neurol 138:169-175, 1996
Ono T, Date I, Imaoka T, Shingo T, Furuta T, Asari S, Ohmoto T: Time course analysis of dopamine-secreting PC12
cells transplanted into the allogeneic or xenogeneic brain . Restor Neurol Neurosci 177, 1996
===============================
1995
Unilateral hypotonic seizures successfully diagnosed by ictal SPECT with technetium-99m-HMPAO in a patient with a brain tumour.
Date I, Kamitani M, Ohmoto T:
J Neurol Neurosurg Psychiat 58:509-510, 1995
Two-year follow-up study of a parkinsonian patient and severe motor fluctuations treated by cografts of adrenal medulla and peripheral nerve into bilateral caudate nuclei.
Date I, Asari S, Ohmoto T:
Neurosurgery 37:515-519, 1995
Good chromaffin cell survival in a parkinsonian patient treated by co-grafts of adrenal medulla and pretransected peripheral nerve.
Date I, Imaoka T, Miyoshi Y, Ono T, Asari S, Ohmoto T:
Restor Neurol Neurosci 59, 1995
Neural transplantation and trophic factors in Parkinson's disease: in relation to cografting of adrenal chromaffin cells and pretransected peripheral nerve.
Date I, Ohmoto T:
Jap J Physiol S311-S312, 1995
Microencapsulated dopamine-secreting cells grafted into the brain.
Date I, Miyoshi Y, Imaoka T, Ono T, Furuta T, Asari S, Ohmoto, T, Iwata H:
Restor Neurol Neurosci 58-59, 1995
Three-dimensional morphological study of microvascular regeneration in cavity wall of the rat cerebral cortex using the scanning electron microscope: implications for delayed neural grafting into brain cavities.
Miyoshi, Y, Date I, Ohmoto T:
Exp Neurol 131:69-82, 1995
Neovascularization of rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex: a three-dimensional morphological study using the scanning electron microscope.
Miyoshi Y, Date I, Ohmoto T:
Brain Res 681:131-140, 1995
Chromaffin cell survival prolonged by nerve growth factor from pretransected sciatic nerve.
Date I, Miyoshi Y, Imaoka T, Ono T, Furuta T, Asari S, Ohmoto T:
Cell Transplantation 4 (Suppl. 1):s19-s21, 1995
Preliminary results of gene transfer to central nervous system by continuous injection of DNA-liposome complex.
Imaoka T, Date I, Miyoshi Y, Ono T, Furuta T, Asari S, Ohmoto T, Yasuda T, Tsuda M:
Cell Transplantation 4 (Suppl.1):s23-s26, 1995
Attempted gene therapy for a Parkinson's disease model.
Imaoka T. Date I, Ono T, Asari S, Ohmoto T:
Restor Neurol Neurosci 9:62, 1995
Attempted gene therapy for Parkinson's disease.
Imaoka T, Date I, Ono T, Asari S, Ohmoto T:
Jap J Physiol S320, 1995
=======================================
1994
Efficacy of pretransection of peripheral nerve for promoting the survival of cografted chromaffin cells and recovery of host dopaminergic fibers in animal models of Parkinson's disease.
Date I, Miyoshi Y, Imaoka T, Furuta T, Asari S, Ohmoto T:
Neurosci Res 20:213-221, 1994
Cografts of adrenal medulla with peripheral nerve for Parkinson's disease.
Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Furuta T, Asari S, Ohmoto T:
Cell Transplantation 3(suppl.1):S47-S49, 1994
Effect of host age upon the degree of nigrostriatal dopaminergic system recovery following cografts of adrenal medulla and pretransected peripheral nerve.
Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Furuta T, Asari S, Ohmoto T:
Brain Res 637:50-56, 1994
Increased nerve growth factor level in the distal stump of transected sciatic nerve in relation to aging and its application for neural grafting.
Date I, Furukawa S, Ohmoto T:
Exp Neurol 130:168-171, 1994
==================================
1993
The effect of a short-course treatment with FK506 on the survivability of rat-to-mouse cross-species neural graft.
Sakai K, Yoshimoto Y, Date I:
Restor Neurol Neurosci 5:131-139, 1993
Direct thrombosis of aneurysms
Kinugasa K, Mandai S, Date I, Ohmoto T:.
J Neurosurg 78:1006-1008, 1993
Improved cryopreservative medium suitable for the freeze-storage and transplantation of fetal neural tissues.
Yoshimoto Y, Date I, Ohmoto T:
Restor Neurol Neurosci 6:73-81, 1993
Long-term outcome in surgically treated spina bifida cystica.
Date I, Yagyu Y, Asari S, Ohmoto T:
Surg Neurol 40:471-475, 1993
Suppression of immunorejection against rat fetal dopaminergic neurons in a mouse brain by 15-deoxyspergualin.
Zhou J, Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:
Brain Res 621:155-160, 1993
Xenogeneic dopaminergic grafts reverse behavioral deficits induced by 6-OHDA in rodents: effect of 15-deoxyspergualin treatment .
Zhou J, Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:
Neurosci Lett 163:81-84, 1993
Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging.
Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Gohda Y, Furuta T, Asari S Ohmoto T:
Brain Res 621:150-154, 1993
Long-term effects of cografts of pretransected peripheral nerve with adrenal medulla in animal models of Parkinson's disease.
Date I, Yoshimoto Y, Gohda Y, Furuta T, Asari S, Ohmoto T:
Neurosurgery 33:685-690, 1993
Long-term outcome in surgically treated encephalocele.
Date I, Yagyu Y, Asari S, Ohmoto T:
Surg Neurol 40:125-130, 1993
The influence of donor age on cografting of adrenal medulla with pretransected peripheral nerve.
Date I, Yoshimoto Y, Miyoshi Y, Imaoka T, Furuta T, Asari S, Ohmoto T:
Brain Res 624:233-238. 1993
===========================
1992
Cografts of adrenal medulla with pretransected peripheral nerve.
Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:
Restor Neurol Neurosci 4:179, 1992
Cografts of adrenal medulla with pretransected peripheral nerve.
Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:
J Neur Transplant Plast 3:251-252, 1992
Mobile schwannoma of the cauda equina.
Satoh T, Kageyama Y, Yoshimoto Y, Kamata I, Date I:
MRI Decisions 6:27-28, 1992
Age-related decline in the dopaminergic nigrostriatal system: the oxidative hypothesis and protective strategies.
Felten DL, Felten SY, Steece-Collier K, Date I, Clemens JA:
Ann Neurol 32 (Suppl):133-136, 1992
===========================
1991
The nigrostriatal dopaminergic system in MPTP-treated mice shows more prominent recovery by syngeneic adrenal medullary graft than by allogeneic or xenogeneic graft.
Date I, Felten SY, Felten DL:
Brain Res 545:191-198, 1991
The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents.
Sakai K, Date I, Yoshimoto Y, Arisawa T, Nakashima H, Furuta T, Asari S, Ohmoto T:
Brain Res 565:167-170, 1991
Stereotaxic injection of GD1a ganglioside induces limited recovery of striatal dopaminergic system in MPTP-treated aging mice.
Date I, Notter MFD, Felten SY, Felten DL:
J Neurosci Res 28:525-530, 1991
A monoclonal antibody that labels Purkinje cells in the rat cerebellum.
Tokunaga A, Ono K, Date I, Arisawa T:
Brain Res Bull 27:669-674, 1991
===============================
1990
MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by stereotaxic injection of acidic fibroblast growth factor (aFGF).
Date I, Notter MFD, Felten SY, Felten DL:
Brain Res 526:156-160, 1990
Limited recovery of striatal dopaminergic fibers by adrenal medullary grafts in MPTP-treated aging mice.
Date I, Felten SY, Olschowka JA, Felten DL:
Exp Neurol 107:197-207, 1990
Long-term effect of MPTP in the mouse brain in relation to aging: neurochemical and immunocytochemical analysis.
Date I, Felten DL, Felten SY:
Brain Res 519:266-276, 1990
Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells and recovery of the host nigrostriatal dopaminergic system in MPTP-treated young adult mice.
Date I, Felten SY, Felten DL:
Brain Res 537:33-39, 1990
=========================================
1989
Exogenous GM1 gangliosides induce partial recovery of the nigrostriatal dopaminergic system in MPTP-treated young mice but not in aging mice.
Date I, Felten SY, Felten DL:
Neurosci Lett 106:282-286, 1989
========================================
1988
Intraparenchymal allografts in the mouse brain in relation to immunocytochemical identification of T lymphocyte subsets.
Date I, Kawamura K, Nakashima H, Ono K, Nishimoto A:
Neurosci Lett 86:17-20, 1988
Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus.
Date I, Kawamura K, Nakashima H:
Exp Brain Res 73:15-22, 1988
Immunological reaction and blood-brain barrier in mouse-to-rat cross-species neural graft.
Nakashima H, Kawamura K, Date I:
Brain Res 475:232-243, 1988
===================================
1986
Endometrial stromal sarcoma metastatic to the skull.
Date I, Yagyu Y, Bukeo T:
Neurol Med Chir 26:571-574, 1986
Primary rhabdomyosarcoma combined with chronic paragonimiasis in the cerebrum: a necropsy case and review of the literature.
Hayashi K, Ohtsuki Y, Ikehara I, Akagi T, Murakami M, Date I, Bukeo T, Yagyu Y:
Acta Neuropathol (Berl) 72:170-177, 1986
