Isao Date, M.D.tate.jpg

 

Professor and Chairman

 

出身地:兵庫県西宮市生まれ、両親とも岡山出身。中学校から岡山で育つ。

 

専門分野

脳神経外科一般

脳動脈瘤、良性脳腫瘍の外科

機能的脳神経外科

脳の再生、細胞移植

くも膜下出血後の脳血管攣縮

小児脳神経外科

 

自己紹介およびメッセージ :

 私は、昭和57年(1982年)に岡山大学医学部を卒業後、初代西本 詮教授(現岡山大学名誉教授)の主宰される当脳神経外科教室に入局し、その後平成2年(1990年)からは2代目大本堯史教授(現岡山大学名誉教授)に御指導をうけ、平成15年(2003年)に第3代の教授となり現在に至っています。

 脳神経外科医としての最初の4年間は、岡山大学脳神経外科と国立岡山病院(現 岡山医療センター)脳神経外科で研修いたしました。その後、大学院生となり、脳の再生・移植の研究を行いました。当時は脳の再生の研究がまさに注目を浴び始めたころで、新しい発見に心をときめかせながら、研究を行っていました。その成果があがって、米国ニューヨーク州のロチェスター大学に昭和63年(1988年)から2年間留学いたしました。留学生活は大変楽しく充実していて、私の人生にとって最高の2年間だったと思います。「留学のすすめ」を岡山医師研修支援機構のホームページに書かせていただいております(http://www.ishikenshuushien.com/new/abroad.php?id=21)。また、基礎研究の経験はその後の私の脳神経外科医としての臨床活動を多いに広げ、また、基礎研究で培った様々な能力(計画作成能力、科学的・論理的思考力など)が臨床の現場で問題解決に役立ちました  (リンク1 PDF1 脳神経外科医教育と基礎研究の意義.pdf )

 平成2年(1990年)に帰国後、大学院生に研究指導をする一方、臨床面では、岡山大学の豊富な症例数を背景に、脳動脈瘤、脳腫瘍を中心にあらゆる分野の脳神経外科疾患の手術経験を積み重ねて参りました。平成15年(2003年)に教授に就任後は、ITを駆使した安全・正確・低侵襲な脳神経外科手術を目指し、コンピュータ連動の脳ナビゲーション手術、高解像度MRIガイド下の定位脳手術、画像の向上著しい神経内視鏡手術などをいち早く導入してきました。教授就任当時は年間300件であった手術件数は、現在年間600件と2倍になっております。良好な手術結果が患者の皆様の評価をいただいているものと思います。

 岡山県のみならず、中国四国や近畿の広い地域から患者の皆様が治療を受けに来られています。外来でも病棟でも患者さんの目線にたって笑顔で接し、安心して治療を受けられるような雰囲気作りを心がけています。

 医学生、研修医に対する教育にも大変力と時間を注いでいます。臨床実習では、私自らの外来で時間をかけて診断と治療の実際を学んでもらっていますし、手術室の中でも手術手順の意味合いや、モニタ画像に映し出される病変や正常解剖などをわかりやすく指導することを心がけています。

 私は、米国留学から帰国後、日本脳神経外科学会の同時通訳団の一員として活動するようになり、平成15年(2003年)からは団長を務めていますリンク2 同時通訳団座談会、 リンク3 同時通訳ブースより。平成24年(2012年)からは日本医学英語教育学会の理事長も務めており、医学の最先端を学び、そして歩んでいく上で、如何に英語が重要かを身にしみて感じております。このことをいつも医学生、研修医に伝える努力を続けています。

 

昭和32 (1957年)730日生まれ

昭和51 (1976年) 岡山大安寺高校卒業

昭和57 (1982年) 岡山大学医学部医学科卒業

昭和63 (1988年) 米国ロチェスター大学医学部留学(2年間)

平成2 (1990年)   岡山大学大学院医学研究科修了、医学博士

平成3 (1991年)   日本脳神経外科学会専門医

平成3 (1991年)   岡山大学脳神経外科助手

平成11 (1999年) 岡山大学脳神経外科講師

平成15 (2003年) 岡山大学教授

平成23 (2011年) 岡山大学病院 副病院長

 

資 格(専門医等)

日本脳神経外科学会専門医

日本脳卒中学会専門医

日本脳卒中の外科学会技術指導医

日本小児神経外科学会認定医

日本神経内視鏡学会技術認定医

日本定位・機能神経外科学会技術認定医

 

受賞歴

平成6(1994年)   日本脳神経外科学会ガレーヌス賞

平成8(1996年)   岡山医学会新見(にいみ)賞

平成10(1998年) 岡山医学会結城(ゆうき)賞

 

主な所属学会 世話人・理事など

全国学会会長

 2008年 スパズムシンポジウム会長

 2009年 日本脳神経外科コングレス会長

 2009年 日本分子脳神経外科学会会長

 2011年 日本神経内視鏡学会会長

 2012年 日本脳神経減圧術学会会長

 2012年 日本小児神経外科学会会長 

 2013年 日本定位・機能神経外科学会会長

 2015年 日本医学英語教育学会会長

 2015年 日本正常圧水頭症学会会長

 2016年 日本脳卒中の外科学会会長

 2019年 脳神経外科手術と機器学会会長

 2019年 日本整容脳神経外科学会会長

 2020年 日本脳神経外科学会会長


主な学会役員

 日本脳神経外科学会理事(医療問題検討委員会委員長)

 日本脳神経外科同時通訳団団長

 日本医学英語教育学会理事長

 日本正常圧水頭症学会理事長

 日本整容脳神経外科学会理事長

 スパズム・シンポジウム 世話人代表

 日本脳卒中の外科学会理事

 日本脳腫瘍の外科学会理事

 日本頭蓋底外科学会理事

 日本神経内視鏡学会理事

 日本小児神経外科学会理事

 日本定位・機能神経外科学会理事

 日本脳神経外傷学会理事

 日本ニューロリハビリテーション学会理事 

 日本脳循環代謝学会理事


主な論文・著書

 

2015

 

Onishi M, Ichikawa T, Kurozumi K, Inoue S, Maruo T, Otani Y, Fujii K, Ishida J, Shimazu Y, Yoshida K, Michiue H, Chiocca EA, Date I: Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Brain Tumor Pathology DOI 10.1007/s10014-015-0216-6, 2015

 

Shimazu Y, Kurozumi K, Ichikawa T, Fujii K, Onishi M, Ishida J, Oka T, Watanabe M, Nasu Y, Kumon H, Date I: Integrin antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3 gene therapy for malignant glioma. Gene Therapy 22:146-154, 2015

 

Toyoshima A, Yasuhara T, Kameda M, Morimoto J, Takeuchi H, Wang F, Sasaki T, Sasada S, Shinko A, Wakamori T, Okazaki M, Kondo A, Agari T, Borlongan CV, Date I: Intra-arterial transplantation of allogeneic mesenchymal stem cells mounts neuroprotective effects in a transient ischemic stroke model in rats: Analyses of therapeutic time window and its mechanisms. PLOS ONE DOI 10.1371/journal.pone.0127302, 2015

 

Yasuhara T, Kameda M, Agari T, Date I: Regenerative medicine for Parkinson's disease. Neurol Med Chir (Tokyo) 55:113-123, 2015

 

Hishikawa T, Date I, Tokunaga K, Tominari S, Nozaki K, Shiokawa Y, Houkin K, Murayama Y, Ishibashi T, Takao H, Kimura T, Nakayama T, Morita A: Risk of rupture of unruptured cerebral aneurysms in elderly patients. Neurology 85:1879-1885, 2015

 

Watson N, Ji X, Yasuhara T, Date I, Kaneko Y, Tajiri N , Borlongan CV: No pain, no gain: lack of exercise obstructs neurogenesis. Cell Tranplant 24:591-597, 2015

 

Ishida J, Kurozumi K, Ichikawa T, Otani Y, Onishi M, Fujii K, Shimazu Y, Oka T, Shimizu T, Date I: Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma. Brain Tumor Pathology 32:245-252, 2015

 

==============================

2014

 

Hishikawa T, Sugiu K, Hiramatsu M, Haruma J, Tokunaga K, Date I, Sakai N: Nationwide survey of the nature and risk factors of complications in embolization of meningiomas and other intracranial tumors: Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET. Neuroradiology 56:139-144, 2014

 

Yoshida K, Ichikawa T, Kurozumi K, Yanai H, Onoda K, Date I: Fatal glioblastoma after gamma knife radiosurgery for arteriovenous malformation in a child. Journal of Clinical Neuroscience 21:1453-1455, 2014

 

Kidani N, Onishi M, Kurozumi K, Date I: The supposed intracavernous sinus arachnoid cyst with abducens neuropathy: a case report. Neurologia medico-chirurgica 54:582-586, 2014

 

Hishikawa T, Tokunaga K, Sugiu K, Date I: Long-term outcomes in adult patients with ischemic-type moyamoya disease involving posterior circulation. Acta Neurochirurgica (Wien) 156:1745-1751, 2014

 

Ishida J, Onishi M, Kurozumi K, Ichikawa T, Fujii K, Shimazu Y, Oka T, Date I: Integrin inhibitor suppresses bevacizumab-induced glioma invasion. Translational Oncology 7(2):292-302, 2014

 

Wakamori T, Agari T, Yasuhara T, Kameda M, Kondo A, Shinko A, Sasada S, Sasaki T, Furuta T, Date I: Cognitive functions in Parkinson's disease: Relation to disease severity and hallucination. Parkinsonism and Related Disorders 20:415-420, 2014

 

Ichikawa T, Kurozumi K, Michiue H, Ishida J, Maeda Y, Kondo E, Kawasaki A, Date I: Reduced neurotoxicity with combined treatment of high-dose methotrexate, cyclophosphamide, doxorubicin, vincristine and prednisolone (M-CHOP) and deferred radiotherapy for primary central nervous system lymphoma. Clinical Neurology and Neurosurgery 127:106-111, 2014

 

Yasuhara T, Takahashi Y, Hijikata Y, So T, Kumamoto S, Nakahara M, Tanoue T, Kusumegi A, Inoue T, Ogawa K, Manabe H, Miyoshi Y, Date I, Nishida K: Infectious spondylitis: Characteristics of geriatric patients and significance of surgery. J Spine Neurosurg 3:2, 2014

 

Hishikawa T, Takasugi Y, Shimizu T, Haruma J, Hiramatsu M, Tokunaga K, Sugiu K, Date I: Cerebral vasospasm in patients over 80 years treated by coil embolization for ruptured cerebral anerurysms. BioMed Research International 2014:253867, 2014

 

Tokunaga K, Hishikawa T, Sugiu K, Date I: Combined transarterial and transvenous approach for curative obliteration of Klippel-Trenaunay-Weber syndrome-associated spinal perimedullary arteriovenous fistulas. Clin Neuroradiol 25:291-294, 2014

 

Tajiri N, Acosta SA, Gonzales-Portillo GS, Aguirre D, Reyes S, Lozano D, Pabon MM, Dela Pena I, Ji X, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV: Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke. Frontiers in Cellular Neuroscience 8:227, 2014

 

Shinko A, Agari T, Kameda M, Yasuhara T, Kondo A, Tayra JT, Sato K, Sasaki T, Sasada S, Takeuchi H, Wakamori T, Borlongan CV, Date I: Spinal cord stimulation exerts neuroprotective effects against experimental Parkinson's disease. PLoS One          2014 Jul 10;9(e101468. doi: 10.1371/journal.pone.0101468. eCollection, 2014

 

Okuma Y, Liu K, Wake H, Liu R, Nishimura Y, Hui Z, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M: Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction. Neuropharmacology 85:18-26, 2014

 

==============================

2013

 

       Onishi M, Ichikawa T, Kurozumi K, Fujii K, Yoshida K, Inoue S, Michiue H, Chiocca EA, Kaur B, Date I: Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models. Neuropathology 33:162-174, 2013

 

Tayra JT, Kameda M, Yasuhara T, Agari T, Kadota T, Wang F, Kikuchi Y, Liang H, Shinko A, Wakamori T, Vcelar B, Weik R, Date I: The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease. Brain Research 1502:55-70, 2013

 

Onishi M, Kurozumi K, Ichikawa T, Michiue H, Fujii K, Ishida J, Shimazu Y, Chiocca EA, Kaur B, Date I: Gene expression profiling of the anti-glioma effect of cilengitide. SpringerPlus 2:160 doi:10.1186/2193-1801-2-160, 2013

 

Maruo T, Ichikawa T, Kanzaki H, Inoue S, Kurozumi K, Onishi M, Yoshida K, Kambara H, Ouchida M, Shimizu K, Tamaru S, Chiocca EA, Date I: Proteomics-based analysis of invasion-related proteins in malignant gliomas. Neuropathology 33(3):264-275, 2013

 

Itami H, Tokunaga K, Okuma Y, Hishikawa T, Sugiu K, Ida K, Date I: Novel 3D-CT evaluation of carotid stent volume: greater chronological expansion of stents in patients with vulnerable plaques. Neuroradiology 55:1153-1160, 2013

 

Fujii K, Kurozumi K, Ichikawa T, Onishi M, Shimazu Y, Ishida J, Chiocca EA, Kaur B, Date I: The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus. Cacer Gene Therapy 20:437-444, 2013

 

Onishi M, Kurozumi K, Ichikawa T, Date I: Mecanisms of tumor development and anti-angiogenic therapy in glioblastoma multiforme. Neurologia medico-chirurgica 53:755-763, 2013

 

Hishikawa T, Tokunaga K, Sugiu K, Date I: Assessment of the difference in posterior circulation involvement between pediatric and adult patients with moyamoya disease. Journal of Neurosurgery 119(4):961-965, 2013

 

Yasuhara T, Agari Y, Kameda M, Kondo A, Kuramoto S, Jing M, Sasaki T, Toyoshima A, Sasada S, Sato K, Shinko A, Wakamori T, Okuma Y, Miyoshi Y, Tajiri N, Borlongan CV, Date I: Regenerative medicine for epilepsy: From basic research to clinical application. International Journal of Molecular Sciences 14:23390-23401, 2013

 

Sato K, Kameda M, Yasuhara T, Agari T, Baba T, Wang F, Shinko A, Wakamori T, Toyoshima A, Takeuchi H, Sasaki T, Sasada S, Kondo A, Borlongan, Matsumae M, Date I: Neuroprotective effects of liraglutide for stroke model of rats. International Journal of Molecular Sciences 14:21513-21524, 2013

 

Okuma Y, Wang F, Toyoshima A, Kameda M, Hishikawa T, Tokunaga K, Sugiu K, Liu K, Haruma J, Nishibori M, Yasuhara T, Date I: Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury. Neuroscience letters (Neurosci Lett) 554:156-161, 2013


==============================

2012


        Tanaka R, Yumoto T, Shiba N, Okawa M, Yasuhara T, Ichikawa T, Tokunaga K,   Date I,  Ujike Y: Overheated and 

        melted intracranial pressure transducer as cause of thermal brain injury during magnetic resonance imaging. 

         J Neurosurg. 2012 Oct 12. [Epub ahead of print]

 

        Onishi M, Ichikawa T, Kurozumi K, Fujii K, Yoshida K, Inoue S, Michiue H, Chiocca EA, Kaur B, Date I:

        Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models.Neuropathology. 2012 

        Sep 19. [Epub ahead of print]

 

        Kurozumi K, Ichikawa T, Onishi M, Fujii K,  Date ICilengitide treatment for malignant glioma: current status and future

        direction. Neurol Med Chir (Tokyo). 2012;52(8):539-47.

.

        Agari T, Kobayashi K, Watanabe K,  Date I., Ohtsuka Y: Cryptogenic West syndrome and subsequent mesial 

        temporal lobe epilepsy. Epileptic Disord. 2012 Sep;14(3):334-9.

 

        Hishikawa T, Tokunaga K, Sugiu K,  Date IClinical and radiographic features of moyamoya disease in patients with 

        both cerebral ischaemia and haemorrhage. Br J Neurosurg. 2012 Aug 30. [Epub ahead of print]

 

        Okuma Y, Liu K, Wake H, Zhang J, Maruo T,  Date I., Yoshino T, Ohtsuka A, Otani N, Tomura S, Shima K, 

        Yamamoto Y, Yamamoto H, Takahashi HK, Mori S, Nishibori M: Anti-high mobility group box-1 antibody therapy for 

        traumatic brain injuryAnn Neurol. 2012 Sep;72(3):373-84.

 

        Tajiri N, Acosta S, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T,  Date I., Solomita MA, Antonucci I, 

        Stuppia L, Kaneko Y, Borlongan CV: Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell 

        proliferation and attenuate behavioral deficits in ischemic stroke rats. PLoS One. 2012;7(8):e43779. Epub 2012 

        Aug 17.

 

        Agari T,  Date ISpinal cord stimulation for the treatment of abnormal posture and gait disorder in patients with 

       Parkinson's disease. Neurol Med Chir (Tokyo). 2012;52(7):470-4.

 

        Tokunaga K, Hishikawa T, Sugiu K,  Date IFatal outcomes of pediatric patients with moyamoya disease associated 

        with pulmonary arterial hypertension. Report of two cases. Clin Neurol Neurosurg. 2012 May 22. [Epub ahead of print]

 

        Iwado E, Ichikawa T, Kosaka H, Otsuka S, Kambara H, Tamiya T, Kondo S,  Date IRole of VEGF and matrix 

        metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas.

        Neuropathology. 2012 Mar 15. [Epub ahead of print]

 

        Kondo A,  Date I., Endo S, Fujii K, Fujii Y, Fujimaki T, Hasegawa M, Hatayama T, Hongo K, Inoue T, Ishikawa M, 

        Ito M, Kayama T, Kohmura E, Matsushima T, Munemoto S, Nagahiro S, Ohno K, Okamura T, Ryu H, Shigeno T, 

        Shirane R, Tagusagawa Y, Tanabe H, Yamada K, Yamakami I: A proposal for standardized analysis of the results of 

        microvascular decompression for trigeminal neuralgia and hemifacial spasm. Acta Neurochir (Wien). 2012 May;154 

        (5):773-8.


=========================

2011


        Nishida A, Tokunaga K, Hishikawa T, Sugiu K,  Date IEndovascular coil embolization of a ruptured distal anterior 

        choroidal artery aneurysm associated with ipsilateral middle cerebral artery occlusion--case report. Neurol Med Chir

        (Tokyo). 2011;51(10):716-9.

 

        Oi S, Inagaki T, Shinoda M, Takahashi S, Ono S,  Date I., Nomura S, Miwa T, Araki T, Ito S, Uchikado H, Takemoto O,

        Shirane R, Nishimoto H, Tashiro Y, Matsumura A; COE-Fetal and Congenital Hydrocephalus Top 10 Japan Study 

        Group.Guideline for management and treatment of fetal and congenital hydrocephalus: Center Of Excellence-Fetal 

        and Congenital Hydrocephalus Top 10 Japan Guideline 2011. Childs Nerv Syst. 2011 Oct;27(10):1563-70.

 

        Hayashi N, Murai H, Ishihara S, Kitamura T, Miki T, Miwa T, Miyajima M, Nishiyama K, Ohira T, Ono S, Suzuki T, 

        Takano S,  Date I., Saeki N, Endo S: Nationwide investigation of the current status of therapeutic neuroendoscopy for 

        ventricular and paraventricular tumors in Japan. J Neurosurg. 2011 Dec;115(6):1147-57.

 

         Ichikawa T, Hamazaki S, Sakai N, Otsuki Y, Wataya T, Kambara H, Shuin T,  Date IMixed germ cell tumor and 

         hemangioblastoma in the cerebellum: report of a rare coexistence. Brain Tumor Pathol. 2011 Jul;28(3):279-84.

 

         Ichikawa T, Agari T, Kurozumi K, Maruo T, Satoh T,  Date I"Double-stick tape" technique for transposition of an 

         offending vessel in microvascular decompression: technical case report. Neurosurgery. 2011 Jun;68(2 Suppl 

         Operative):377-82; discussion 382.

 

         Hayase H, Tokunaga K, Nakayama T, Sugiu K, Nishida A, Arimitsu S, Hishikawa T, Ono S, Ohta M,  Date I

         Computational fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on 

         postoperative patient-specific computed tomography angiography and ultrasound flow data. Neurosurgery. 2011 

          Apr;68(4):1096-101; discussion 1101.

 

         Morimoto T, Yasuhara T, Kameda M, Baba T, Kuramoto S, Kondo A, Takahashi K, Tajiri N, Wang F, Meng J, Ji YW, 

         Kadota T, Maruo T, Kinugasa K, Miyoshi Y, Shingo T, Borlongan CV,  Date IStriatal stimulation nurtures endogenous

         neurogenesis and angiogenesis in chronic-phase ischemic stroke rats. Cell Transplant. 2011;20(7):1049-64.

 

         Wang F, Kameda M, Yasuhara T, Tajiri N, Kikuchi Y, Liang HB, Tayra JT, Shinko A, Wakamori T, Agari T,  Date I

         GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson's

         disease. Neurosci Res. 2011 Sep;71(1):92-8.

 

         Kikuchi Y, Yasuhara T , Agari T , Kondo A , Kuramoto S , Kameda M , Kadota T , Baba T , Tajiri N , Wang F , 

         Tayra JT , Liang H , Miyoshi Y , Borlongan CV ,  Date IUrinary 8-OHdG elevations in a partial lesion rat model of 

         Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletionJournal of Cellular

         Physiology 226(5): 1390-1398, 2011

 

         Onishi M, Ichikawa T, Kurozumi K,  Date IAngiogenesis and invasion in gliomaBrain Tumor Pathology 28(1): 13-

         24, 2011

 

         Miyoshi Y, Yasuhara T,  Date IPosterior decompression of far-out foraminal stenosis caused by a lumbosacral 

         transitional vertebra - case report -  Neurol Med Chir (Tokyo) 51: 153-156, 2011

 

         Miyoshi Y, Yasuhara T, Nishida A, Tokunaga K,Sugiu K,  Date IEffectiveness of intraoperative near-infrared 

         indocyanine green videoangiography in a case with recurrent spinal perimedullary arteriovenous fistulaClinical 

         Neurology and Neurroscience 113: 239-242, 2011

 

         Takahashi C , Okudera H , Origasa H , Takeuchi E , Nakamura K , Fukuda O ,  Date I. , Tokutomi T , Aruga T , 

         Sakamoto S , Kobata H , Ohta T: A simple and useful coma scale for patients with neurologic emergencies: the 

         emergency coma scaleAmerican Journal of Emergency Medicine 29: 196-202, 2011

 

         Kuramoto S, Yasuhara T, Agari T, Kondo A, Jing M, Kikuchi Y, Shinko A, Wakamori T, Kameda M, Wang F, Kin K, 

         Edahiro S, Miyoshi Y,  Date I.BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats. Brain

         Research 1368: 281-289, 2011

 

         Yasuhara T , Ichikawa T , Miyoshi Y , Kurozumi K , Maruo T , Yanai H ,  Date IPrimary Germinoma in the Medulla 

         Oblongata: Case reportNeurologia medico-chirurgica 51(4): 326-329, 2011

 

         Hayase H , Tokunaga K , Nakayama T , Sugiu K, Nishida A, Hishikawa T , Ono S , Ohta M ,  Date IComputational 

         fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on postoperative 

         patient-specific computed tomography angiography and ultrasound flow dateNeurosurgery 68(4): 1096-1101, 2011

 

         Yasuhara T, Miyoshi Y,  Date IChiari Malformation with Thick Occipital BoneActa Med. Okayama 65: 59-61, 2011

 

         Miyoshi Y, Yasuhara T,  Date INoonan syndrome with occipito-atlantal dislocation and upper cervical cord 

         compression due to C1 dysplasia and basilar invaginationNeurol Med Chir (Tokyo) 51: 463-466, 2011

 

         Wang F, Yasuhara T, Kameda M,  Date IMesenchymal stem cell transplantation therapy for Parkinson's disease 

         and cerebral ischemiaCurrent Trends in Neurology 5: 13-16, 2011

 

         Yasuhara T, Tokunaga K, Hishikawa T, Ono S, Miyoshi Y, Sugiu K,  Date IPosterior reversible encephalopathy 

         syndromeJ Clin Neurosci 18: 406-9, 2011

 

         Nishida A, Tokunaga K, Hishikawa T, Sugiu K,  Date IEndovascular coil embolization of a ruptured distal anterior 

         choroidal artery aneurysm associated with ipsilateral middle cerebral artery occlusion: Case reportNeurologia 

         medico-chirurgica 51(10): 716-719, 2011

 

         Yasuhara T, Miyoshi Y,  Date IDevelopment of cervical subarachnoid hematoma following coronal artery stenting for

         angina pectorisNeurol Med Chir (Tokyo) 51: 6646, 2011

 

          Ichikawa T , Agari T , Kurozumi K , Maruo T , Satoh T ,  Date I"Double stick tape" technique for transposition of an

          offending vessel in microvascular decompression: Technical case reportNeurosurgery 68(ONS Suppl 2): ons375-

          ons376, 2011 DOI: 10.1227/NEU.0b013e318217141c

 

          Ichikawa T , Hamazaki S , Sakai N , Otsuki Y , Wataya T , Kambara H , Shuin T ,  Date IMixed germ cell tumor and

          hemangioblastoma in the cerebellum: report of a rate coexistenceBrain Tumor Pathology 28: 279-284, 2011

 

==========================

2010


          Janowski M  Walczak P ,  Date IIntravenous route of cell delivery for treatment of neurological disorders: a meta-

          analysis of preclinical resultsStem Cells and Development 19(1): 5-6, 2010

 

          Kobayashi K , Agari T , Oka M, Yoshinaga H ,  Date I. , Ohtsuka Y , Gotman J : Detection of seizure-associated 

          high-frequency oscillations above 500HzEpilepsy Research 88: 139-144, 2010 

 

          Tajiri N , Yasuhara T , Shingo T , Kondo A, Yuan W, Kadota T , Wang F, Baba T , Tayra JT , Morimoto T, Jing M , 

          Kikuchi Y , Kuramoto S , Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I , Furuta T ,  Date IExercise exerts 

          neuroprotective effects on Parkinson's disease model of ratsBrain Research 1310: 200-207, 2010 

 

          Nishiguchi M, Ono S, Iseda K, Manabe H, Hishikawa T,  Date IEffect of vasodilation by milrinone, a 

          phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: 

          Effectiveness of cisternal injection of milrinoneNeurosurgery 66(1): 158-164, 2010

 

          Katsumata A , Sugiu K , Tokunaga K , Kusaka N , Watanabe K , Nishida A, Namba K , Hamada H , Nakashim H , 

          Date I  Optimal dose of plasmid vascular endothelial growth factor for enhancement of angiogenesis in the rat brain

          ischemia model. Neurologia medico-chirurgica 50(6): 449-455, 2010 

 

          Miyoshi Y , Yasuhara T, Omori M ,  Date IInfantile cervical intramedullary cavernous angioma manifesting as 

          hematomyelia - case report-Neurologia medico-chirurgica 50: 677-682, 2010

 

          Tokunaga K , Sugiu K , Yoshino K , Terai Y , Imaoka T , Handa A , Hirotsune N ,Kusaka N,  Date IPercutaneous 

          balloon angioplasty for acute occlusion of intracranial arteriesNeurosurgery 67[ONS Suppl 1]: ons189-197, 2010

 

          Date ISymptomatic unruptured cerebral aneurysms: Features and surgical outcomeNeurologia medico-chirurgica

          50(9): 788-799, 2010

 

          Wang F, Yasuhara T, Shingo T, Kameda M, Tajiri N, Yuan WJ, Kondo A, Kadota T, Baba T, Tayra JT, Kikuchi Y, 

          Miyoshi Y,  Date IIntravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian

          model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1αBMC Neuroscience 11(52): 1-9,

          2010

 

=========================

2009


          Janowski M ,  Date ISystemic neurotransplantation--a problem-oriented systematic reviewRev Neurosci 20(1): 39-

          60, 2009

 

          Kadota T, Shingo T, Yasuhara T, Tajiri N, Kondo A, Morimoto T, Yuan WJ, Wang F, Baba T, Tokunaga K, 

          Miyoshi Y,  Date I Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon

          Parkinson's disease model of rats with enhanced neurogenesis. Brain Research 1254: 120-127, 2009

 

          Date I., Yasuhara T: Neurological disorders and neural regeneration, with special reference to Parkinson's disease 

          and cerebral ischemiaThe Japanese Society for Artificial Organs 12: 11-16, 2009

 

          Yasuhara T, Agari T, Kanbara H, Ichikawa T, Kurozumi K, Ono S, Miyoshi Y, Tokunaga K, Date I: Parkinsonism 

          Related to Brain Tumors: A Case Report and Review of the literatureThe Open Neurosurgery Journal 2: 4-7, 2009 

 

          Ogawa T , Ono S , Ichikawa T , Arimitsu S), Onoda K , Tokunaga K , Sugiu K , Tomizawa K , Matusi H ,  Date I

          Protein transduction method for cerebrovascular disordersActa Med Okayama 63(1): 1-7, 2009 

 

          Satoh T, Omi M , Nabeshima M , Onoda K,  Date ISeverity analysis of neurovascular contact in patients with 

          trigeminal neuralgia: assessment with the inner view of the 3D MR cisternogram and angiogram fusion imaging. 

          AJNR Am J Neuroradiol 30(3): 603-607, 2009 

 

          Kuramoto S, Yasuhara T, Agari T, Kondo A, Matsui T, Miyoshi Y, Shingo T,  Date IInjection of muscimol, a GABAa 

          agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdala-kindled rats.

          Neurological Research 31: 407-13, 2009 

 

          Kondo A, Shingo T, Yasuhara T, Kuramoto S, Kameda M, Kikuchi Y, Matsui T, Miyoshi Y, Agari T, Borlongan CV,  

          Date IErythropoietin exerts anti-epileptic effects with the suppression of aberrant new cell formation in the 

          dentate gyrus and upregulation of neuropeptide Y in seizure model of rats. Brain Res 1296: 127-36, 2009 

 

          Jing M, Shingo T, Yasuhara T, Kondo A, Morimoto T, Wang F, Baba T, Yuan WJ, Tajiri N, Uozumi T, Murakami M, 

          Tanabe M, Miyoshi Y, Zhao S,  Date I The combined therapy of intrahippocampal transplantation of adult neural 

          stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of

          abnormal mossy fiber sprouting. Brain Res 1295: 203-217, 2009 

 

          Baba T , Kameda M , Yasuhara T , Morimoto T , Kondo A, Shingo T , Tajiri N , Wang F, Miyoshi Y , Borlongan CV, 

          Matumae M ,  Date I Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and 

          anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/akt signaling pathway. Stroke 

          published online Sep 17: , 2009 

 

          Sugiu K, Agari T, Tokunaga K, Nsihida A,  Date IEndovascular treatment for bow hunter's syndrome: case report.

          Minim Invas Neurosurg 52: 193-195, 2009

 

          Sugiu K, Tokunaga K, Ono S, Nishida A,  Date IRebleeding from a vertebral artery dissecting aneurysm after 

          endovascular internal trapping: adverse effect of intrathecal urokinase injection or incomplete occlusion?: Case 

          report. Neurologia medico-chirurgica 49(12): 597-600, 2009 

 

====================================================

2008


          Onoda K, Ono S, Tokunaga K, Sugiu K, Date IFenestration of the supraclinoid internal carotid artery with 

          associated aneurysm. Neurol Med Chir (Tokyo) 48(3):118-120, 2008

 

          Agari T, Yasuhara T, Matusi T, Kuramoto S, Kondo A, Miyoshi Y, Shingo T, Borlongan CV, Date IIntrapallidal 

          metabotropic glutamate receptor activation in a rat model of Parkinson's disease:  Behavioral and histological 

          analysis. BRAIN RESEARCH 1203:189-196, 2008

 

          Kondo E, Tanaka T, Miyake T, Ichikawa T, Hirai M, Adachi M, Yoshikawa K, Ichimura K, Ohara N, Moriwaki A, Date I,

          Ueda R, Yoshino T:Potent synergy of dual antitumor peptides for growth suppression of human glioblastoma cell 

          lines. Mol Cancer Ther 7(6):1461-1471, 2008

 

          Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T, 

          Wang F, Leung H, Matsui T, Miyoshi Y, Date INeuroprotective effects of edaravone-administration on 6-OHDA-

          treated dopaminergic neurons. BioMedCentral Neurosciences 9:75, 2008

 

          Takahashi K, Yasuhara T, Shingo T, Muraoka K, Kameda M, Takeuchi A, Yano A, Kurozumi K, Agari T, Miyoshi Y, 

          Kinugasa K, Date IEmbryonic neural stem cells transplanted in middle cerebral artery occlusion model of rats 

          demonstrated potent therapeutic effects, compared to adult neural stem cells. Brain Res 1234:172-182, 2008

 

          Hishikawa T, Ono S, Ogawa T, Tokunaga K, Sugiu K, Date IEffects of deferoxamine-activated hypoxia-inducible 

          factor-1 on the brain stem after subarachnoid hemorrhage in rats. Neurosurgery 62(1):232-241, 2008

 

          Sugiu K, Tokunaga K, Nishida A, Hayase H, Ono S, Onoda K, Date IEndovascular treatment for ruptured cerebral 

          aneurysms in elderly patients. Journal of Stroke & Cerebrovascular Disease 17(5)Supplement 1:S92, 2008

 

          Kuramoto S, Yasuhara T, Agari T, Kondo A, Matsui T, Miyoshi Y, Shingo T, Date IInjection of muscimol, a GABAa 

          agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdalakindled rats. Neurol 

          Res. Sep 29: 2008

 

          Date I, Shingo T, Yasuhara T: Neurotransmitter and neurotrophic factor-secreting cell line grafting for the treatment 

            of Parkinson's disease. Advances in Alzheimer's and Parkinson's Disease. Abraham Fisher, Maurizio Memo, 

          Fabrizio Stocchi, Israel Hanin eds. Springer, New York pp51-56, 2008

 

          Muraoka K, Shingo T, Yasuhara T, Kameda M, Yuen WJ, Uozumi T, Matsui T, Miyoshi Y, Date IComparison of the 

          therapeutic potential of adult and embryonic neural precursor cells in a rat model of Parkinson disease. Journal of 

          Neurosurgery 108(1):149-159, 2008

 

          Ono S, Arimitsu S, Ogawa T, Manabe H, Onoda K, Tokunaga K, Sugiu K, Date IContinuous evaluation of regional 

          oxygen saturation in cerebral vasospasm after subarachnoid haemorrhage using INVOS®, portable near infrared 

          spectrography. Acta Neurochir Suppl 104:215-218, 2008

 

          Ono S, Hishikata T, Ogawa T, Nishiguchi M, Onoda K, Tokunaga K, Sugiu K, Date IEffect of deferoxamine-activated

          hypoxia inducible factor-1 on the brainstem following subarachnoid haemorrhage. Acta Neurochir Suppl 104:69-73,

          2008

 

          Ogawa T, Ono S, Ichikawa T, Michiue H, Arimitus S, Onoda K, Tokunaga K, Sugiu K, Tomizawa K, Matusi H, 

          Date IDirect protein transduction method to cerebral arteries by using 11R: new strategy for the treatment of     

          cerebral vasospasm after subarachnoid haemorrhage. Acta Neurochir Suppl 104:161-163, 2008

 

          Ogawa T, Ono S, Ichikawa T, Arimitsu S, Onoda K, Tokunaga K, Sugiu K, Tomizawa K, Matusi H, Date I

          Endothelia nitric oxide synthase-11R protein therapy for prevention of cerebral vasospasm in rats: a preliminary 

          report. Acta Neurochir Suppl 104:165-167, 2008

 

          Iseda K, Ono S, Onoda K, Satoh M, Manabe H, Nishiguchi M, Takahashi K, Tokunaga K, Sugiu K, Date I

          Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage.

          Journal of Neurosurgery 107:128135, 2007

 

          Yasuhara T, Hara K, Maki M, Matsukawa N, Fujino H, Date I, Borlongan CV: Lack of exercise, via hindlimb 

          suspension, impedes endogenous neurogenesis. Neuroscience 149:182-191, 2007

 

         Yasuahra T, Shingo T, Date I: Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease.

         Acta Med Okayama 61(2):51-56, 2007

 

         Yasuhara T, Date I: Intracerebral transplantation of genetically engineered cells for Parkinson's disease: Toward 

         clinical application. Cell Transplantation 16:125-132, 2007

 

         Watanabe K, Sugiu K, Tokunaga K, Sasahara W, Ono S, Date I:Packing efficacy of hydrocoil system: in vitro study 

         using ruptured aneurysm model. Neurosurg Rev 30:127-130, 2007

 

         Satoh T, Onoda K, Date I: Preoperative simulation for microvascular decompression in patients with idiopathic 

         trigeminal neuralgia: Visualization with three-dimensional magnetic resonance cisternogram and angiogram fusion 

         imaging. Neurosurgery 60(1):104-114, 2007

 

         Satoh T, Onoda K, Date I: Fusion imaging of three-dimensional magnetic resonance cisternograms and angiograms 

         for the assessment of microvascular decompression in patients with hemifacial spasms. Journal of Neurosurgery 106

         (1):82-89, 2007

 

         Tsuboi T, Tokunaga K, Shingo T, Itoh T, Mandai S, Kinugasa K, Date I: Differentiation between intradural and 

         extradural locations of juxta-dural ring aneurysms by using contrast-enhanced 3-dimensional time-of-flight magnetic 

         resonance angiography. Surgical Neurology 67(4):381-387, 2007

 

         Ogawa T, Ono S, Ichiakwa T, Arimitsu S, Onoda K, Tokunaga K, Sugiu K, Tomizawa K, Matsui H, Date INovel 

         protein transduction method by using 11R:  an effective new drug delivery system for the treatment of 

         cerebraovascular diseases. Stroke 38(4):1354-1361, 2007

 

         Sugiu K, Tokunaga K, Nishida A, Sasahara W, Watanabe K, Ono S, Onoda K, Date I: Triple-catheter technique in the

         transvenous coil emabolization of an isolated sinus dural arteriovenous fistula. Neurosrugery 61(3 Suppl):81-85, 

         2007

 

         Kameda M, Shingo T, Takahashi K, Muraoka K, Kurozumi K, Yasuhara T, Maruo T, Tsuboi T,  Uozumi T, Matsui T, 

         Miyoshi Y, Hamada H, Date I: Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate

         and integrate after intracerebral transplantation in rats with transient forebrain ischemia. European Journal of 

         Neuroscience 26:1462-1478, 2007

 

==================================

2006

 

         Yasuhara T, Borlongan CV, Date IEx vivo gene therapy:  transplantation of neurotrophic factor-secreting cells for 

         cerebral ischemia. Frontiers in Bioscience 11:760-775, 2006

 

         Kusaka N, Tamiya T, Adachi Y, Katayama S, Namba S, Tokunaga K, Sugiu K, Date I, Ohmoto T: Adult unilateral 

         moyamoya disease with familial occurrence in two definite cases: a case report and review of the literature.

         Neurosurgical Review 29(1):82-87, 2006

 

         Tokunaga K, Tamiya T, Date ITransient memory disturbance after removal of an intraventricular trigonal meningioma

         by a parieto-occipital interhemispheric precuneus approach: case report.  Surgical Neurology 65:167-169, 2006

 

         Muraoka K, Shingo T, Yasuhara T, Kameda M, Yuan W, Hayase H, Matsui T, Miyoshi Y, Date I: The high integration 

         and differentiation potential of autologous neural stem cell transplantation compared with allogeneic transplantation in

         adult rat hippocampus. Experimental Neurology 199:311-327, 2006

 

         Kobayashi K, Yasuhara T, Agarai T, Muraoka K, Kameda M, Yuan W, Hayase H, Matsui T, Miyoshi Y, Shingo T, 

         Date I: Control of dopamine-secretion by Tet-Off system in an in vivo model of parkinsonian rat. Brain Research 

         1102:1-11, 2006

 

         Nakama H, Ohsugi K, Otsuki T, Date I, Kosuga M, Okuyama T, Sakuragawa N: Encapsulation cell therapy for 

         mucopolysaccharidosis type VII using genetically engineered immortalized human amniotic epithelial cells. Tohoku J

         Exp Med 209(1):23-32, 2006

 

         Tamiya T, Takao S, Ichikawa T, Chayama K, Date I: Successful chemotherapy for congenital malignant gliomas: A 

         report of two cases. Pediat Neurosurg 42:240-244, 2006

 

         Saoth T, Omi M, Ohsako C, Fujiwara K, Tsuno K, Sasahara W, Onoda K, Tokunaga K, Sugiu K, Date I: Differential 

         Diagnosis of the Infundibular Dilation and Aneurysm of Internal Carotid Artery: Assessment with Fusion Imaging of 

         3D MR Cistenography/Angiography. AJNR Am J Neuroradiol 27:306-312, 2006

 

         Date I, Shingo T, Yasuhara T: Genetically modified cell line grafting for the treatment of Parkinson's disease. 

         Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology. Kanno T, Kato Y (eds), Springer-Verlag 

         Tokyo, Tokyo 108-113, 2006

 

         Date I, Shingo T, Yasuhara T, Takahashi K, Muraoka K: Neuroprotection and repair by using adult-derived neural 

         stem cell grafting for neurological disorders. Minimally Invasive Neurosurgery and Multidisciplinary 

         Neurotraumatology. Kanno T, Kato Y (eds), Springer-Verlag Tokyo, Tokyo 131-137, 2006

 

====================================

2005

    Yasuhara T, Shingo T, Muraoka K, Kameda M, Agari T, WenJi Y, Hishikawa T, Matsui T, Miyoshi Y, Kimura T, 

         Borlongan CV, Date IToxicity of semaphorin3A for dopaminergic neurons. Neuroscience Letters 382:61-65, 2005

 

         Sugiu K, Tokunaga K, Watanabe K, Sasahara W, Ono S, Tamiya T, Date IEmergent endovascular treatment of 

         ruptured vertebral artery dissecting aneurysms. Neuroradiology 47:158-164, 2005

 

         Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Ishii K, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, 

         Honmou O, Houkin K, Date I, Hamada H: Mesenchymal stem cells that produce neurotrophic factors reduce ischemic

         damage in the rat middle cerebral artery occlusion model. Molecular therapy 11:96-104, 2005

 

         Katsuragi S, Ikeda T, Date I, Shingo T, Yasuhara T, Mishima K, Aoo N, Harada K, Egashira N, Iwasaki K, Fujiwara M, 

         Ikenoue T: Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting

         learning impairment following neonatal hypoxic-ischemica brain insult in rats. Am J Obstet Gynecol 192:1028-1037, 

         2005

 

          Katsuragi S, Ikeda T, Date I, Shingo T, Yasuhara T, Ikenoue T: Grafting of glial cell line-derived neurotrophic factor 

          secreting cells for hypoxic-ischmic encephalopathy in neonatal rats. Am J Obstet Gynecol 192:1137-1145, 2005

 

          Yasuhara T, Shingo T, Muraoka K, Kobayashi K, Takeuchi A, Yano A, Yuan WJ, Kameda M, Matsui T, Miyoshi Y, 

          Date IEarly transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell 

          demonstrating strong neuroprotective effects in a rat model of Parkinson disease. J Neurosurg 102:80-89, 2005

 

          Yasuhara T, Shingo T, Muraoka K, Yuan WJ, Kameda M, Takeuchi A, Yano A, Nishio S, Matusi T, Miyoshi Y, 

          Hamada H, Date IThe differences between high and low-dose administration of VEGF to dopaminergic neurons of 

          in vitro and in vivo Parkinson's disease model. Brain Research 1038:1-10, 2005

 

          Miyoshi T, Otsuka F, Suzuki J, Inagaki K, Takeda M, Kano Y, Yamashita T, Ogura T, Date I, Tanaka Y, Hashimoto K,

          Makino H: Periodic secretion of adrenocorticotropin in a patient with cushing's disease manifested during pregnancy.

          Endocrine Journal 52(3):287-292, 2005

 

          Ono S, Onoda K, Tokunaga K, Sugiu K, Date ICombination therapy for cerebral vasospasm after SAH:  Importance

          of spinal drainage and intraarterial injection of fasudil hydrochloride. 13 World Congress of Neurological surgery, 

          June19-24:379-385, 2005

 

          Yano A, Shingo T, Takeuchi A, Yasuhara T, Kobayashi K, Takahashi K, Muraoka K, Matsui T, Miyoshi Y, Hamada H,

          Date IEncapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic 

          effects on focal cerebral ischemia. J Neurosurg 103:104-114, 2005

 

          Yasuhara T, Shingo T, Muraoka K, Kameda M, Agari T, Yuan WJ, Hayase H, Hamada H, Borlongan CV, Date I

          Neurorescue effects of VEGF on a rat model of Parkinson's disease. Brain Research 1053:10-18, 2005

 

          Kusaka N, Sugiu K, Tokunaga K, Katsumata A, Nishida A, Namba K, Hamada H, Nakashima H, Date IEnhanced 

          brain angiogenesis in chronic cerebral hypoperfusion after administration of plasmid human vascular endothelial 

          growth factor in combination with indirect vasoreconstructive surgery. Journal of Neurosurgery 103:882-890, 2005

 

          Sugiu K, Tokunaga K, Watanabe K, Sasahara W, Tagawa M, Tamesa N, Ono S, Onoda K, Date I: Endovascular 

          treatment for elderly patients with ruptured aneurysm. Acta Neurochirurgica Supplementum 94:7-9, 2005

 

          Satoh M, Date I, Ohmoto T, Perkins E, Parent AD: The expression and activation of matrix metalloproteinase-1 after

          subarachnoid haemorrhage in rats. Acta Neurochir (Wien) 147(2):187-193, 2005

 

          Satoh T, Omi M, Ohsako T, Katsumata A, Yoshimoto Y, Tsuchimoto S, Onoda K, Tokunaga K, Sugiu K, Date I

          Visualization of Aneurysmal Contours and Perianeurysmal Environment with Conventional and Transparent 3D MR 

          Cisternography. AJNR Am J Neuroradiol 26:313-318, 2005


          Satoh T, Omi M, Ohsako T, Katsumata A, Yoshimoto Y, Tsuchimoto S, Onoda K, Tokunaga K, Sugiu K, Date I 

          Influence of Perianeurysmal Environment on the Deformation and Bleb Formation of the Unruptured Cerebral 

          Aneurysm: Assessment with Fusion Imaging of 3D MR Cisternography and 3D MR Angiography. AJNR Am J 

          Neuroradiol 26:2010-2018, 2005

 

          Michiue H, Tomizawa K, Matsushita M, Tamiya T, Lu YF, Ichikawa T, Date I, Matsui H: Ubiquitination-Resistant p53 

          Protein Transduction Therapy Facilitates Anti-Cancer Effect on the Growth of Human Malignant Glioma Cells. FEBS

          Letter 579:3965-3969, 2005


          Michiue H, Tomizawa K, Wei FW, Tamiya T, Matsushita M, Lu YF, Ichikawa T, Date I, Matsui H: The NH2 terminus of 

          influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 

          protein transduction. Journal of Biological Chemistry 280:8285-8289, 2005


          Ichikawa T, Wakisaka A, Daido S, Takao S, Tamiya T, Date I, Koizumi S, Niida Y: A case of solitary subependymal 

          giant cell astrocytoma: Two somatic hits of TSC2 in the tumor, without evidence of somatic mosaicism. Journal of 

          Molecular Diagnostics 7(4):544-549, 2005

 

          Matsushita H, Uenaka A, Ono T, Hasegawa K, Sato S, Koizumi A, Nakagawa K, Toda M , Shingo T, Ichikawa T, 

          Noguchi Y, Tamiya T, Furuta T, Kawase T, Date I, Nakayama E: Identification of glioma-specific RFx4-E and -F 

          isoforms and humoral immune response in patients. Cancer Science 96(11):801-809, 2005

 

========================================

2004

          Otsuka S, Tamiya T, Ono Y, Michiue H, Kurozumi K, Daido S, Kambara H, Date I, Ohmoto T: The relationship 

          between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in 

          intracranial meningiomas. Journal of Neurooncology 70:349-357, 2004

 

          Yasuhara T, Shingo T, Date IThe potential role of vascular endothelial growth factor in the central nervous system. 

          Rev Neurosci 15:293-307, 2004

 

          Yasuhara T, Sugiu K, Kakishita M, Date IPseudoxanthoma elasticum with carotid rete mirabile. Clin Neurol 

          Neurosurg 106:114-117, 2004

 

          Yasuhara T, Shingo T, Kobayashi K, Takeuchi A, Yano A, Muraoka K, Matsui T, Miyoshi Y, Hamada H, Date I

          Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of 

          Parkinson's disease. Eur J Neurosci 19:1494-1504, 2004

 

          Tokunaga K, Sugiu K, Kameda M, Sakai K, Terasaka K, Higashi T, Date IPersistent primitive trigeminal artery-

          cavernous sinus fistula with intracerebral hemorrhage: endovascular treatment using detachable coils in a 

          transarterial double-catheter technique. J Neurosurg 101:697-699, 2004

 

          Kurozumi K, Nakamura K, Tamiya T, Kawano Y, Kobune M, Hirai S, Uchida H, Sasaki K, Ito Y, Kato K, Honmou O, 

          Houkin K, Date I, Hamada H: BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce

          infarct size in the rat middle cerebral artery occlusion model. Mol Ther 9:189-197, 2004

 

          Miyoshi T, Otsuka F, Takeda M, Inagaki K, Suzuki J, Ogura T, Date I, Hashimoto K, Makino H: Effect of cabergoline 

          treatment on Cushing's disease caused by aberrant adrenocorticotropin-secreting macroadenoma. J Endocrinol 

          Invest 27:1055-1059, 2004

 

          Ono S, Ichikawa T, Ono Y, Date ILarge supratentorial ectopic ependymoma with massive calcification and cyst 

          formation. Neurol Med Chir 44:424-428, 2004

 

          Sugiu K, Tokunaga K, Sasahara W, Watanabe K, Nishida A, Katsumata A, Kusaka N, Date I, Ohmoto T, 

          Rufenacht DA: Training in neurovascular intervention: usefulness of in-vitro model and clinical practice. 

          Interventional Neuroradiology 10 (Suppl 1):107-112, 2004

 

          Daido S, Takao S, Tamiya T, Ono Y, Terada K, Ito S, Ouchida M, Date I, Ohmoto T, Shimizu K: Loss of 

          heterozygosity on chromosome 10q associated with malignancy and prognosis in astrocytic tumors, and discovery of

          novel loss regions. ONCOLOGY REPORTS 12:789-795, 2004

 

          Hishikawa T, Ono S, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date IExpression of hypoxia inducible factor-1 in

          a rat subarachnoid hemorrhage model. Cerebral Vasospasm Advances in Research and Treatment. Macdonald RL

          (ed), Thieme Medical Publishers, Inc. New York 134-137, 2004

 

          Hishikawa T, Ono S, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date IIntravascular adenoviral gene transfection

          of monkey cerebra arteries using micro-balloon catheters. Cerebral Vasospasm Advances in Research and 

          Treatment. Macdonald RL (ed), Thieme Medical Publishers, Inc., New York 112-115, 2004

 

          Ono S, Hishikawa T,  Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date ITherapeutic strategies for cerebral 

          vasospasm after SAH: efficacy of a combination of intraventricular urokinase and intra-arterial Fasudil. Cerebral 

          Vasospasm Advances in Research and Treatment. Macdonald RL (ed), Thieme Medical Publishers, Inc., New York 

          296-299, 2004

 

          Ono S, Hishikawa T, Nishiguchi M, Nishio S, Tokunaga K, Sugiu K, Date IWhat is the key factor expressed in 

          human spastic arteries after SAH? Cerebral Vasospasm Advances in Research and Treatment. Macdonald RL (ed),

          Thieme Medical Publishers, Inc., New York 129-133, 2004


          Nishiguchi M, Ono S, Hishikawa T, Nishio S, Tokunaga K, Sugiu K, Date IPhosphodiesterase III inhibitor for the 

          treatment of chronic cerebral vasospasm in dogs. Cerebral Vasospasm Advances in Research and Treatment. 

          Macdonald RL (ed), Thieme Medical Publishers, Inc., New York 160-163, 2004

 

======================

2003

          Ono S, Date I, Onoda K, Ohmoto T: Time course of the diameter of the major cerebral arteries after subarachnoid 

          hemorrhage using corrosion cast technique. Neurol Res 25:383-389, 2003

 

          Terada H, Matsushita M, Lu, YF, Shirai T, Li ST, Tomizawa K, Moriwaki A, Nishio S, Date I, Ohmoto T, Matsui H: 

          Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide.  J Neurochem 87:

          1145-1151, 2003

 

          Yoshida H, Date I, Shingo T, Fujiwara K, Kobayashi K, Miyoshi Y, Ohmoto T: Stereotactic transplantation of a 

          dopamine-producing capsule into the striatum for treatment of Parkinson disease: a preclinical primate study. 

          J Neurosurg 98:874-881, 2003

 

          Yasuhara T, Tamiya T, Meguro T, Ichikawa T, Sato Y, Date I, Nakashima H, Ohmoto T: Glioblastoma with metastasis 

          to the spleen: case report. Neurol Med Chir (Tokyo) 43:452-456, 2003

 

          Fujiwara K, Date I, Shingo T, Yoshida H, Kobayashi K, Takeuchi A, Yano A, Tamiya T, Ohmoto T: Reduction of infarct

          volume and apoptosis by grafting of encapsulated basic fibroblast growth factor-secreting cells in a model of middle 

          cerebral artery occlusion in rats. J Neurosurg 99:1053-1062, 2003

 

          Shingo T, Date I, Yano A, Kobayashi K, Takeuchi A, Yasuhara T, Ohmoto T: Cell therapy for cerebral ischemia using 

          vascular endothelial growth factor-secreting cells. Molecular mechanism and epochal therapeutics of ischemic stroke

          and dementia. Abe K (ed), Elsevier Science BV, Amsterdam 483-487, 2003

 

          Date I, Shingo T, Ohmoto T: Neurotrophic factor delivery by encapsulated cell grafts. Molecular mechanism and 

          epochal therapeutics of ischemic stroke and dementia. Abe K (ed), Elsevier Science BV, Amsterdam 247-251, 2003

 

================================================

2002 

          Naganawa Y, Ohsugi K, Kase R, Date I, Sakuraba H, Sakuragawa N: In vitro study of encapsulation therapy for 

          Fabry disease using genetically engineered CHO cell line. Cell Transplant 11:325-329, 2002

 

          Shingo T, Date I, Yoshida H, Ohmoto T: Neuroprotective and restorative effects of intrastriatal grafting of 

          encapsulated GDNF-producing cells in a rat model of Parkinson's disease. J Neurosci Res 69:946-954, 2002

 

         Seth K, Agrawal AK, Date I, Seth PK: The role of dopamine in manganese-induced oxidative injury in rat 

         pheochromocytoma cells. Hum Exp Toxicol 21:165-170, 2002

 

=====================================

2001

         Fujiwara K, Date I, Shingo T, Yoshida H, Kobayashi K, Takeuchi A, Tamiya T, Ohmoto T: Neurotrophic factor-secreting

         cell grafting for cerebral ischemia: preliminary report. Cell Transplant 10:419-422, 2001

 

         Nakajima M, Date I, Takahashi K, Ninomiya Y, Asari S, Ohmoto T: Effects of aging on cerebral vasospasm after 

         subarachnoid hemorrhage in rabbits. Stroke 32:620-628, 2001

 

         Tokunaga K, Kusaka N, Nakashima H, Date I, Ohmoto T: Coil embolization of intradural pseudoaneurysms caused by

         arterial injury during surgery: report of two cases. AJNR Am J Neuroradiol 22:35-39, 2001

 

         Date I, Shingo T, Yoshida H, Fujiwara K, Kobayashi K, Takeuchi A, Ohmoto T: Grafting of encapsulated genetically 

         modified cells secreting GDNF into the striatum of parkinsonian model rats. Cell Transplantation 10:397-401, 2001

 

         Date I, Nakajima M, Takahashi K, Ono S, Satoh M, Iseda K, Manabe H, Ninomiya Y, Asari S, Ohmoto T: Comparison

         of cerebral vasospasm between young and old animals: preliminary report. Acta Neurochir Suppl 77:111-114, 2001

 

         Satoh M, Date I, Nakajima M, Takahashi K, Iseda K, Tamiya T, Ohmoto T, Ninomiya Y, Asari S: Inhibition of poly(ADP-

         ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits. Stroke 32:225-231, 

         2001

 

         Iseda K, Date I, Manabe H, Nishiguchi M, Ono S, Ohmoto T: Caspase inhibitor attenuates cerebral vasospasm in 

        animal models of subarachnoid hemorrhage. Proceedings 12th World Congress of Neurosurgery (World Federation of

        Neurosurgical Societies). 150-151, 2001

 

        Date I, Shingo T, Ohmoto T: Neurotrophic factor delivery by encapsulated cell grafting technique. Molecular 

        Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis, Abe K (ed), Elsevier Science B.V., Amsterdam 289-

        296, 2001

 

===========================

2000

        Date I, Shingo T, Yoshida H, Fujiwara K, Kobayashi K, Ohmoto T: Grafting of encapsulated dopamine-secreting cells in

        Parkinson's disease: long-term primate study. Cell Transplantation 9:705-709, 2000

 

        Aoi M, Date I, Tomita S, Ohmoto T: The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic

        system in hemiparkinsonian rats: behavioral and histological studies using two different dosages. Neurosci Res 36:319

        -325, 2000

 

        Aoi M, Date I, Tomita S, Ohmoto T: Single or continuous injection of glial cell line-derived neurotrophic factor into the 

        striatum induces recovery of the nigrostriatal dopaminergic system. Neurol Res 22:832-836, 2000

 

        Aoi M, Date I, Tomita S, Ohmoto T: Single administration of GDNF into the striatum induced protection and repair of 

        the nigrostriatal dopaminergic system in the intrastriatal 6-hydroxydopamine injection model of hemiparkinsonism. 

        Restor Neurol Neurosci 17:31-38, 2000

 

        Aoi M, Date I, Tomita S, Ohmoto T: GDNF induces recovery of the nigrostriatal dopaminergic system in the rat brain 

        following intracerebroventricular or intraparenchymal administration. Acta Neurochir (Wien) 142:805-810, 2000

 

        Date INeural transplantation and trophic factors for the treatment of Parkinson's disease. Stem Cell Biology and 

        Cellular and Molecular Treatment. Sakuragawa N(ed), National Center of Neurology and Psychiatry, Tokyo 75-87, 

        2000

 

=========================

1999

 

        Date I, Ohmoto T: Neural transplantation for Parkinson's disease. Cell Mol Neurobiol 19:67-78, 1999

 

        Date I, Sugiu K, Ohmoto T: A Giant thrombosed aneurysm of the petrous carotid artery presenting with cavernous 

        sinus syndrome: Case report. Skull Base Surg 9:65-70, 1999

 

        Yoshida H, Date I, Shingo T, Fujiwara K, Miyoshi Y, Furuta T, Ohmoto T: Evaluation of reaction of primate brain to 

        grafted PC12 cells. Cell Transplant 8:427-430, 1999

 

        Date I, Ono S, Takahashi K, Nakajima M, Onoda K, Ogihara K, Shiota T, Asari S, Ohmoto T, Ninomiya Y, Yabuno N: 

        Quantitative and qualitative analysis of hemolysate-induced cerebral vasospasm in rats using corrosion cast 

        technique. Cerebral Vasospasm VI. Dorsch N (ed), Oslington Consulting PTY LTD, Leichhardt, Australia 36-39, 1999

 

        Ono S, Date I, Takahashi K, Nakajima M, Shiota T, Asari S, Ohmoto T, Ninomiya Y, Yabuno N:  In vivo analysis of 

        transcription factors in rat basilar artery with cerebral vasospasm after subarachnoid hemorrhage. Cerebral 

        Vasospasm VI, Dorsch N (ed), Oslington Consulting PTY LTD, Leichhardt, Australia 86-88, 1999

 

============================

1998

 

        Ono S, Date I, Onoda K, Shiota T, Ohmoto T, Ninomiya Y, Asari S, Morishita R: Decoy administration of NF-κB into the

        subarachnoid space for cerebral angiopathy. Hum Gene Ther 9:1003-1011, 1998

 

        Date I, Ohmoto T: Long-term outcome of surgical treatment of intracavernous giant aneurysms. Neurol Med Chir 38 

        (Suppl):62-69, 1998

 

        Date I, Asari S, Ohmoto T: Cerebral aneurysms causing visual symptoms: their features and surgical outcome. Clin 

        Neurol Neurosurg 100(4):259-267, 1998

 

        Date I, Ogihara K, Tamiya T, Ohmoto T: Kissing bilateral large carotid-ophthalmic aneurysms: a case report. 

        Neurosurg Rev 21:281-283, 1998

 

        Date I, Asari S, Ohmoto T: Tips for preventing CSF rhinorrhea after acoustic neurinoma surgery: technical note. Skull

        Base Surg 8:181-183, 1998

 

        Date I, Shingo T, Yoshida H, Fujiwara K, Ohmoto T: Delivery of neurotransmitter and neurotrophic factors into the brain

        using an encapsulated cell grafting technique. Restor Neurol Neurosci 13:222-223, 1998

 

        Yoshida H, Date I, Shingo T, Fujiwara K, Ohmoto T: Evaluation of encapsulated and unencapsulated PC12 cells 

        grafted into the primate brain. Restor Neurol Neurosci 13:223-224, 1998 


        Date I, Aoi M, Tomita S, Collins F, Ohmoto T: GDNF administration induces recovery of the nigrostriatal dopaminergic

        system both in young and aged parkinsonian mice. Neuroreport 9:2365-2369, 1998

 

        Fujiwara K, Date I, Shingo T, Yoshida H, Imaoka T, Ohmoto T: Establishment of a glucocorticoid-inducible L-DOPA and

        dopamine-producing PC12 cell line using non-viral transfection of human tyrosine hydroxylase gene. Restor Neurol 

        Neurosci  13:229, 1998

 

        Imaoka T, Date I, Ohmoto T, Nagatsu T: Significant behavioral recovery in Parkinson's disease model by direct 

        intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex. Hum Gene Ther 9:1093-

        1102, 1998

 

        Imaoka T, Date I, Ohmoto T, Yasuda T, Tsuda M: In vivo gene transfer into the adult mammalian central nervous 

        system by continuous injection of plasmid DNA-cationic liposome complex. Brain Res 780:119-128, 1998

 

        Date I, Ohmoto T: ntracerebral chromaffin cell and encapsulated cell grafting for Parkinson's disease : a review The 

        adrenal chromaffin cell.  I. Archetype and exemplar of cellular signalling in secretory control. Kanno T, Nakazato Y, 

        Kumakura K(ed), Hokkaido University Press, Sapporo 333-342, 1998

 

=========================================

1997

        Ohmoto T, Yabuno N, Date I: Surgical treatment of transitional internal carotid aneurysms. J Clin Neurosci 4:373-377,

        1997

 

        Ono S, Date I, Nakajima M, Onoda K, Ogihara K, Shiota T, Asari S, Ninomiya Y, Yabuno N, Ohmoto T: Three-

        dimensional analysis of vasospastic major cerebral arteries in rats with the corrosion cast technique. Stroke 28:1631-

        1638, 1997

        

        Date I, Akioka T, Ohmoto T: Penetration of the optic chiasm by a ruptured anterior communicating artery aneurysm.

        J Neurosurg 87:324-326, 1997


        Date I, Shingo T, Ohmoto T, Emerich DF: Long-term enhanced chromaffin cell survival and behavioral recovery in 

        hemiparkinsonian rats with co-grafted polymer-encapsulated human NGF-secreting cells. Exp Neurol 147:10-17, 1997

 

        Ono T, Date I, Imaoka T, Shingo T, Furuta T, Asari S, Ohmoto T: Evaluation of intracerebral grafting of dopamine-

        secreting PC12 cells into allogeneic and xenogeneic brain. Cell Transplantation 6:511-513, 1997

 

==================================

1996

        Date I, Ohmoto T: Parkinson's disease (Neurosurgical forum). J Neurosurg 85:528-529, 1996

  

        Date I, Ohmoto T, Imaoka T, Ono T, Hammang JP, Francis J, Greco C, Emerich DF: Cografting with polymer-

        encapsulated human nerve growth factor-secreting cells and chromaffin cell survival and behavioral recovery in 

        hemiparkinsonian rats. J Neurosurg 84:1006-1012, 1996

 

        Date I, Miyoshi Y, Imaoka T, Ono T, Furuta T, Asari S, Ohmoto T Iwata H: Preliminary report of polymer encapsulated 

        dopamine-secreting cell grafting into the brain. Cell Transplantation 5:S17-S19, 1996

        

        Date I, Imaoka T, Ono T, Shingo, T, Furuta T, Asari S, Emerich DF, Ohmoto T: Encapsulated NGF-secreting cell 

        grafting into the brain: increased chromaffin cell survival and functional recovery in parkinsonian model rats. Restor 

        Neurol Neurosci  10:182, 1996

 

        Date I, Ohmoto T: Neural transplantation and trophic factors in Parkinson's disease: special reference to chromaffin 

        cell grafting, NGF support from pretransected peripheral nerve and encapsulated dopamine-secreting cell grafting. 

        Exp Neurol 137:333-344, 1996

 

        Date IParkinson's disease, trophic factors, and adrenal medullary chromaffin cell grafting: basic and clinical studies.

        Brain Res Bull 40:1-19, 1996

  

        Date I, Imaoka T, Miyoshi Y, Ono T, Asari S, Ohmoto T: Chromaffin cell survival and host dopaminergic fiber recovery 

        in a patient with Parkinson's disease treated by cografts of adrenal medulla and pretransected peripheral nerve: case 

        report. J Neurosurg      84:685-689, 1996

        

        Date I, Ohmoto T, Imaoka T, Shingo T, Emerich DF: Chromaffin cell survival from both young and old donors is 

        enhanced by cografts of polymer-encapsulated human NGF-secreting cells. Neuroreport 7:1813-1818, 1996

 

        Miyoshi Y, Date I, Ohmoto T, Iwata H: Histological analysis of microencapsulated dopamine-secreting cells in agarose/

        poly(styrene sulfonic acid) mixed gel xenotransplanted into the brain. Exp Neurol 138:169-175, 1996

 

        Ono T, Date I, Imaoka T, Shingo T, Furuta T, Asari S, Ohmoto T: Time course analysis of dopamine-secreting PC12 

        cells transplanted into the allogeneic or xenogeneic brain . Restor Neurol Neurosci  177, 1996

 

===============================

1995

 

Unilateral hypotonic seizures successfully diagnosed by ictal SPECT with technetium-99m-HMPAO in a patient with a brain tumour.

Date I, Kamitani M, Ohmoto T:

J Neurol Neurosurg Psychiat 58:509-510, 1995

 

Two-year follow-up study of a parkinsonian patient and severe motor fluctuations treated by cografts of adrenal medulla and peripheral nerve into bilateral caudate nuclei.

Date I, Asari S, Ohmoto T:

Neurosurgery 37:515-519, 1995

 

Good chromaffin cell survival in a parkinsonian patient treated by co-grafts of adrenal medulla and pretransected peripheral nerve.

Date I, Imaoka T, Miyoshi Y, Ono T, Asari S, Ohmoto T:

Restor Neurol Neurosci 59, 1995

 

Neural transplantation and trophic factors in Parkinson's disease: in relation to cografting of adrenal chromaffin cells and pretransected peripheral nerve.

Date I, Ohmoto T:

Jap J Physiol S311-S312, 1995

 

Microencapsulated dopamine-secreting cells grafted into the brain.

Date I, Miyoshi Y, Imaoka T, Ono T, Furuta T, Asari S, Ohmoto, T, Iwata H:

Restor Neurol Neurosci 58-59, 1995

 

Three-dimensional morphological study of microvascular regeneration in cavity wall of the rat cerebral cortex using the scanning electron microscope: implications for delayed neural grafting into brain cavities.

Miyoshi, Y, Date I, Ohmoto T:

Exp Neurol 131:69-82, 1995

 

Neovascularization of rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex: a three-dimensional morphological study using the scanning electron microscope.

Miyoshi Y, Date I, Ohmoto T:

Brain Res 681:131-140, 1995

 

Chromaffin cell survival prolonged by nerve growth factor from pretransected sciatic nerve.

Date I, Miyoshi Y, Imaoka T, Ono T, Furuta T, Asari S, Ohmoto T:

Cell Transplantation 4 (Suppl. 1):s19-s21, 1995

 

Preliminary results of gene transfer to central nervous system by continuous injection of DNA-liposome complex.

Imaoka T, Date I, Miyoshi Y, Ono T, Furuta T, Asari S, Ohmoto T, Yasuda T, Tsuda M:

Cell Transplantation 4 (Suppl.1):s23-s26, 1995

 

Attempted gene therapy for a Parkinson's disease model.

Imaoka T. Date I, Ono T, Asari S, Ohmoto T:

Restor Neurol Neurosci 9:62, 1995

 

Attempted gene therapy for Parkinson's disease.

Imaoka T, Date I, Ono T, Asari S, Ohmoto T:

Jap J Physiol S320, 1995

 

=======================================

1994

 

Efficacy of pretransection of peripheral nerve for promoting the survival of cografted chromaffin cells and recovery of host dopaminergic fibers in animal models of Parkinson's disease.

Date I, Miyoshi Y, Imaoka T, Furuta T, Asari S, Ohmoto T:

Neurosci Res 20:213-221, 1994

 

Cografts of adrenal medulla with peripheral nerve for Parkinson's disease.

Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Furuta T, Asari S, Ohmoto T:

Cell Transplantation 3(suppl.1):S47-S49, 1994

 

Effect of host age upon the degree of nigrostriatal dopaminergic system recovery following cografts of adrenal medulla and pretransected peripheral nerve.

Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Furuta T, Asari S, Ohmoto T:

Brain Res 637:50-56, 1994

 

Increased nerve growth factor level in the distal stump of transected sciatic nerve in relation to aging and its application for neural grafting.

Date I, Furukawa S, Ohmoto T:

Exp Neurol 130:168-171, 1994

 

==================================

1993

 

The effect of a short-course treatment with FK506 on the survivability of rat-to-mouse cross-species neural graft.

Sakai K, Yoshimoto Y, Date I:

Restor Neurol Neurosci  5:131-139, 1993

 

Direct thrombosis of aneurysms

Kinugasa K, Mandai S, Date I, Ohmoto T:.

J Neurosurg 78:1006-1008, 1993

 

Improved cryopreservative medium suitable for the freeze-storage and transplantation of fetal neural tissues.

Yoshimoto Y, Date I, Ohmoto T:

Restor Neurol Neurosci 6:73-81, 1993

 

Long-term outcome in surgically treated spina bifida cystica.

Date I, Yagyu Y, Asari S, Ohmoto T:

Surg Neurol 40:471-475, 1993

 

Suppression of immunorejection against rat fetal dopaminergic neurons in a mouse brain by 15-deoxyspergualin.

Zhou J, Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:

Brain Res 621:155-160, 1993

 

Xenogeneic dopaminergic grafts reverse behavioral deficits induced by 6-OHDA in rodents: effect of 15-deoxyspergualin treatment         .

Zhou J, Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:

Neurosci Lett 163:81-84, 1993

 

Enhanced recovery of the nigrostriatal dopaminergic system in MPTP-treated mice following intrastriatal injection of basic fibroblast growth factor in relation to aging.

Date I, Yoshimoto Y, Imaoka T, Miyoshi Y, Gohda Y, Furuta T, Asari S Ohmoto T:

Brain Res 621:150-154, 1993

 

Long-term effects of cografts of pretransected peripheral nerve with adrenal medulla in animal models of Parkinson's disease.

Date I, Yoshimoto Y, Gohda Y, Furuta T, Asari S, Ohmoto T:

Neurosurgery 33:685-690, 1993

 

Long-term outcome in surgically treated encephalocele.

Date I, Yagyu Y, Asari S, Ohmoto T:

Surg Neurol 40:125-130, 1993

 

The influence of donor age on cografting of adrenal medulla with pretransected peripheral nerve.

Date I, Yoshimoto Y, Miyoshi Y, Imaoka T, Furuta T, Asari S, Ohmoto T:

Brain Res 624:233-238. 1993

 

===========================

1992

 

Cografts of adrenal medulla with pretransected peripheral nerve.

Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:

Restor Neurol Neurosci 4:179, 1992

 

Cografts of adrenal medulla with pretransected peripheral nerve.

Date I, Sakai K, Yoshimoto Y, Furuta T, Asari S, Ohmoto T:

J Neur Transplant Plast 3:251-252, 1992

 

Mobile schwannoma of the cauda equina.

Satoh T, Kageyama Y, Yoshimoto Y, Kamata I, Date I:

 MRI Decisions 6:27-28, 1992

 

Age-related decline in the dopaminergic nigrostriatal system: the oxidative hypothesis and protective strategies.

Felten DL, Felten SY, Steece-Collier K, Date I, Clemens JA:

Ann Neurol 32 (Suppl):133-136, 1992

 

===========================

1991

 

The nigrostriatal dopaminergic system in MPTP-treated mice shows more prominent recovery by syngeneic adrenal medullary graft than by allogeneic or xenogeneic graft.

Date I, Felten SY, Felten DL:

Brain Res 545:191-198, 1991

 

The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents.

Sakai K, Date I, Yoshimoto Y, Arisawa T, Nakashima H, Furuta T, Asari S, Ohmoto T:

Brain Res 565:167-170, 1991

 

Stereotaxic injection of GD1a ganglioside induces limited recovery of striatal dopaminergic system in MPTP-treated aging mice.

Date I, Notter MFD, Felten SY, Felten DL:

J Neurosci Res 28:525-530, 1991

 

A monoclonal antibody that labels Purkinje cells in the rat cerebellum.

Tokunaga A, Ono K, Date I, Arisawa T:

Brain Res Bull 27:669-674, 1991

 

===============================

1990

 

MPTP-treated young mice but not aging mice show partial recovery of the nigrostriatal dopaminergic system by stereotaxic injection of acidic fibroblast growth factor (aFGF).

Date I, Notter MFD, Felten SY, Felten DL:

Brain Res 526:156-160, 1990

 

Limited recovery of striatal dopaminergic fibers by adrenal medullary grafts in MPTP-treated aging mice.

Date I, Felten SY, Olschowka JA, Felten DL:

Exp Neurol 107:197-207, 1990

 

Long-term effect of MPTP in the mouse brain in relation to aging: neurochemical and immunocytochemical analysis.

Date I, Felten DL, Felten SY:

Brain Res 519:266-276, 1990

 

Cografts of adrenal medulla with peripheral nerve enhance the survivability of transplanted adrenal chromaffin cells and recovery of the host nigrostriatal dopaminergic system in MPTP-treated young adult mice.

Date I, Felten SY, Felten DL:

Brain Res 537:33-39, 1990

 

=========================================

1989

 

Exogenous GM1 gangliosides induce partial recovery of the nigrostriatal dopaminergic system in MPTP-treated young mice but not in aging mice.

Date I, Felten SY, Felten DL:

Neurosci Lett 106:282-286, 1989

 

========================================

1988

 

Intraparenchymal allografts in the mouse brain in relation to immunocytochemical identification of T lymphocyte subsets.

Date I, Kawamura K, Nakashima H, Ono K, Nishimoto A:

Neurosci Lett 86:17-20, 1988

 

Histological signs of immune reactions against allogeneic solid fetal neural grafts in the mouse cerebellum depend on the MHC locus.

Date I, Kawamura K, Nakashima H:

Exp Brain Res 73:15-22, 1988

 

Immunological reaction and blood-brain barrier in mouse-to-rat cross-species neural graft.

Nakashima H, Kawamura K, Date I:

Brain Res          475:232-243, 1988

 

===================================

1986

 

Endometrial stromal sarcoma metastatic to the skull.

Date I, Yagyu Y, Bukeo T:

Neurol Med Chir 26:571-574, 1986

 

Primary rhabdomyosarcoma combined with chronic paragonimiasis in the cerebrum: a necropsy case and review of the literature.

Hayashi K, Ohtsuki Y, Ikehara I, Akagi T, Murakami M, Date I, Bukeo T, Yagyu Y:

Acta Neuropathol (Berl) 72:170-177, 1986

 

 

 

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